{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:19:13Z","timestamp":1791292753684,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>In patients with unilateral vocal fold paralysis (UVFP), laryngeal electromyography (LEMG) occasionally observes synkinesis in laryngeal muscles, a condition that could impair vocal fold mobility and voice control. This study aims to evaluate the impact of synkinesis on UVFP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A retrospective case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Patients with UVFP onset &gt;6\u00a0months were recruited (N = 104). The outcome measurements included LEMG, quantitative LEMG analysis of thyroarytenoid\u2013lateral cricoarytenoid (TA\u2010LCA) muscle complex, glottal gap measured by videolaryngostroboscopy, voice\u2010related quality of life, and voice acoustic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the LEMG analysis, 8 patients (8%) had synkinesis, and 96 (92%) did not. In the synkinesis group, TA\u2010LCA turn frequency in the lesioned side was comparable to that in the healthy side (<jats:italic>P<\/jats:italic> =. 52). Patients in the synkinesis group had higher TA\u2010LCA turn frequency (<jats:italic>P<\/jats:italic> =. 001), higher probability of cricothyroid muscle dysfunction (<jats:italic>P =<\/jats:italic>. 04), and better voice\u2010related quality of life (<jats:italic>P<\/jats:italic> =. 01) but objective voice outcomes comparable to those in the nonsynkinesis group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with synkinesis will have near\u2010complete restoration in TA\u2010LCA turn frequency but still experience voice impairment, a finding that is compatible with the mechanism of aberrant reinnervation. However, patients with synkinesis have better disease\u2010related quality of life than do those without synkinesis.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599817721688","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T08:00:27Z","timestamp":1501574427000},"page":"1017-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Implications of Synkinesis in Unilateral Vocal Fold Paralysis"],"prefix":"10.1002","volume":"157","author":[{"given":"Yu\u2010Cheng","family":"Pei","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan"},{"name":"Center of Vascularized Tissue Allograft Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan"},{"name":"Healthy Aging Research Center Chang Gung University Taoyuan Taiwan"},{"name":"School of Medicine Chang Gung University Taoyuan 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