{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:13:51Z","timestamp":1761293631321,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Surgery is the primary treatment modality for node\u2010positive cutaneous squamous cell carcinoma of the head and neck with no distant disease (HNcSCC\u2010M0). The role of preoperative positron emission tomography\/computed tomography (PET\/CT) scan for these patients is unclear. We compared preoperative PET\/CT with final histopathology among patients undergoing lymphadenectomy and\/or parotidectomy for HNcSCC\u2010M0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single Australian center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Investigation included disease parameters and preoperative CT and PET\/CT findings of 64 patients with node\u2010positive HNcSCC without distant metastatic disease. Fisher\u2019s exact test was used to test for a difference in the proportion of patients with chronic lymphocytic leukemia between the false\u2010 and true\u2010negative PET\/CT subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 64 patients who underwent PET\/CT prior to surgery for node\u2010positive HNcSCC\u2010M0, 56 underwent a neck dissection and 30, a parotidectomy. Of these, 13\u00a0neck dissections and 2 parotidectomies were performed in the absence of FDG\u2010avid (18F\u2010fludeoxyglucose) nodes in these nodal fields. The PET\/CT positive predictive value of the neck was 91.1%. The negative predictive values in the neck and parotid regions were 60%. Of the false\u2010negative subgroup, 66.7% had chronic lymphocytic leukemia, compared with 11.1% of the true\u2010negative subgroup (<jats:italic>P<\/jats:italic> =. 09). Based on PET\/CT findings, surgical plans according to preoperative CT were changed for 6.25% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Use of PET\/CT for surgical candidates with node\u2010positive HNcSCC\u2010M0 has high specificity and positive predictive value with relatively low sensitivity and negative predictive value. A statistical trend toward a higher rate of chronic lymphocytic leukemia among patients with false\u2010negative results is suggested.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599817731735","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T08:01:18Z","timestamp":1505808078000},"page":"122-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Preoperative Positron Emission Tomography for Node\u2010Positive Head and Neck Cutaneous Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"158","author":[{"given":"Nir","family":"Hirshoren","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology Peter MacCallum Cancer Centre Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Olayos","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Peter MacCallum Cancer Centre Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Herschtal","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Peter MacCallum Cancer Centre Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aravind S.","family":"Ravi Kumar","sequence":"additional","affiliation":[{"name":"Department of Cancer Imaging Peter MacCallum Cancer Centre Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Gyorki","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Peter MacCallum Cancer Centre Melbourne Australia"},{"name":"Department of Surgery University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"120","article-title":"Epidemiology of skin cancer","volume":"810","author":"Leiter U","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10830.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12282"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12553"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0985-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20576"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042728-200504000-00011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-008-1192-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2014.01.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.08.014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24683"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599817731735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599817731735","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599817731735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:06:27Z","timestamp":1760958387000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599817731735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,19]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1177\/0194599817731735"],"URL":"https:\/\/doi.org\/10.1177\/0194599817731735","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2017,9,19]]},"assertion":[{"value":"2017-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}