{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T01:55:02Z","timestamp":1784426102990,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Evaluating the long\u2010term outcomes of vocal fold structural fat grafting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Seventy\u2010nine dysphonic patients (16\u201082 years; 55 with unilateral laryngeal paralysis and 24 with vocal fold scarring) underwent vocal fold fat injection. Fat was harvested by low\u2010pressure liposuction and then processed by centrifugation. Refined fat aliquots were placed in the vocal fold and paraglottic space in multiple tunnels to enhance graft neovascularization. All patients were followed for 12\u00a0months, 15 for 3 years, and 5 for 10 years with videolaryngostroboscopy, maximal phonation time (MPT) measurement, Voice Handicap Index (VHI) questionnaire, and GRBAS (grade, roughness, breathiness, asthenia, strain) perceptual evaluation. Laryngeal computed tomography (CT) and\/or magnetic resonance imaging (MRI) studies were performed in 16 patients 3 to 28\u00a0months postoperatively; MRI was repeated in 5 cases 12 to 18\u00a0months after the first radiological study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The voice quality of all patients improved after surgery, and long\u2010term stability was confirmed by MPT, GRBAS, and VHI (<jats:italic>P<\/jats:italic> ranging between. 004 and &lt;.001). The results achieved 1 year postoperatively remained stable at 3 and 10 years. Videolaryn\u2010gostroboscopy showed improved glottic closure in all patients despite a limited amount of fat resorption. CT and MRI demonstrated survival of the fat grafts in all of the 16 examined cases. Serial MRI scans showed no change in graft size over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The reported clinical and radiological data demonstrate that fat is an effective filler for permanent vocal fold augmentation if the refined micro\u2010aliquots are placed in multiple tunnels.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599817739256","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T08:02:16Z","timestamp":1511251336000},"page":"135-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Structural Fat Grafting to Improve Outcomes of Vocal Folds\u2019 Fat Augmentation: Long\u2010term Results"],"prefix":"10.1002","volume":"158","author":[{"given":"Giovanna","family":"Cantarella","sequence":"first","affiliation":[{"name":"Otolaryngology Department Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milan 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