{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:08:22Z","timestamp":1787504902801,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the efficacy of budesonide nasal spray on the health\u2010related quality of life and symptoms among children with sleep\u2010disordered breathing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Randomized, parallel, double\u2010blind, placebo\u2010controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Sixty children (ages, 4\u201010 years) who were referred because of snoring and\/or apneas for &gt;3\u00a0months were included between January 2015 and June 2016 and randomized in a double\u2010blind design to treatment with 64 \u03bcg\/mL of budesonide nasal spray (n = 30) or placebo nasal spray (n = 30) twice daily for 6 weeks. The primary outcome measurement was the change in the mean OSA\u201018 total score from baseline. Other variables examined were individual OSA\u201018 domains, a visual analog scale for quality of life, symptoms (snoring, apneas, and nasal obstruction), and adenoid and tonsil size. The trial was investigator initiated and not sponsored by the pharmaceutical industry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010five children completed the trial. An intention\u2010to\u2010treat analysis revealed a significantly greater improvement in the mean OSA\u201018 total score after treatment with budesonide than placebo (19.5 vs 7.5,\n                      <jats:italic>P<\/jats:italic>\n                      =. 0014). Intranasal budesonide also improved 2 OSA\u201018 domains (sleep disturbance, caregivers\u2019 concerns), the visual analog scale score for quality of life, as well as snoring, apneas, and nasal obstruction. No serious adverse events were reported that could be linked to the treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among children with sleep\u2010disordered breathing, 6 weeks\u2019 treatment with intranasal budesonide significantly improved quality of life and symptoms as compared with placebo nasal spray.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599817742597","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T15:07:46Z","timestamp":1511276866000},"page":"752-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Intranasal Budesonide and Quality of Life in Pediatric Sleep\u2010Disordered Breathing: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"158","author":[{"given":"Gunnhildur","family":"Gudnadottir","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Elleg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Halland's Hospital Kungsbacka Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Hellgren","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-135MG"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3116"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215881"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1283"},{"key":"e_1_2_9_6_1","first-page":"224","article-title":"Update on paediatric obstructive sleep apnoea","volume":"8","author":"Dehlink E","year":"2016","journal-title":"J Thorac Dis"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00385-2015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.07.009"},{"key":"e_1_2_9_9_1","first-page":"CD006286","article-title":"Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy","volume":"3","author":"Zhang L","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3398"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.105254"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12717"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25098"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.11.010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.06.009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00808-2016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.2338"},{"key":"e_1_2_9_18_1","unstructured":"Berry RBBR GamaldoCE HardingSM LloydRM MarcusCL VaughnBV.The AASM manual for the scoring of sleep and associated events: rules terminology and technical specifications version 2.2.http:\/\/www.aasmnet.org. 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