{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:26:07Z","timestamp":1791386767223,"version":"4.3.3"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize treatment times in salivary cancer; associate treatment times with patient, tumor, and treatment characteristics; and examine the association of treatment times and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Commission\u2010on\u2010Cancer Accredited Hospitals 2004\u20102013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>In total, 5953 patients with salivary cancer included in the National Cancer Database were identified. For each treatment interval, patients in the fourth quartile (\u201cprolonged\u201d) were compared to patients in the first and second quartiles (\u201cnot prolonged\u201d). Patient, tumor, and treatment characteristics were associated with prolonged times via multivariable binary logistic regression. Prolongation of each interval was associated with overall survival via multivariable Cox proportional hazards regression, controlling for clinically relevant factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median durations for diagnosis\u2010to\u2010treatment initiation, surgery\u2010to\u2010radiation treatment (RT), RT duration, total treatment package, and diagnosis\u2010to\u2010treatment end were 31, 44, 47, 92, and 110\u00a0days, respectively. Race, insurance status, comorbidities, age, T and N stage, facility volume and location, and a facility care transition from diagnosis to initial treatment were associated with prolonged treatment time. Prolonged RT duration was associated with decreased overall survival (OS) (62% vs 75% 5\u2010year OS, HR = 1.26 [95% confidence interval (CI), 1.09\u20101.47]; <jats:italic>P<\/jats:italic> =. 002), but prolonged diagnosis\u2010to\u2010treatment initiation, surgery\u2010to\u2010RT, total treatment package, and diagnosis\u2010to\u2010treatment end intervals were not (70% vs 67% 5\u2010year OS, HR = 1.11 [95% CI, 0.92\u20101.34], <jats:italic>P<\/jats:italic> =. 284; 72% vs 68%, HR = 0.93 [95% CI, 0.79\u20101.09], <jats:italic>P<\/jats:italic> =. 370; 70% vs 70%, HR = 1.00 [95% CI, 0.84\u20101.20], <jats:italic>P<\/jats:italic> =. 974; 66% vs 71%, HR = 0.99 [95% CI, 0.84\u20101.18], <jats:italic>P<\/jats:italic> =. 920, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The median durations identified here can serve as reference points. Radiation therapy duration is associated with overall survival in salivary cancer and could be considered a quality indicator.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818758020","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T11:34:08Z","timestamp":1519126448000},"page":"283-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Treatment Times in Salivary Gland Cancer: National Patterns and Association with Survival"],"prefix":"10.1002","volume":"159","author":[{"given":"Elliot","family":"Morse","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Otolaryngology Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rance J. T.","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Judson","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saral","family":"Mehra","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.3365"},{"key":"e_1_2_7_3_1","unstructured":"WeberRS.Improving the quality of head and neck cancer care.https:\/\/www.ahns.info\/presidents\/documents\/WeberPresidentAddress.pdf. Accessed July 18 2017."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.0657"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.6.672"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23290"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.171"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199903000-00003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058365"},{"key":"e_1_2_7_10_1","first-page":"421","article-title":"A snapshot of waiting times for cancer surgery provided by surgeons affiliated with regional cancer centres in Ontario","volume":"165","author":"Simunovic M","year":"2001","journal-title":"CMAJ"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02374-0"},{"key":"e_1_2_7_12_1","first-page":"187","article-title":"Delay in breast cancer: a review of the literature","volume":"20","author":"Caplan LS","journal-title":"Public Health Rev"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3800-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.04.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10208"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25734"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.03.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)02049-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)04469-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10038"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.12.005"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23419"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.08.046"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00339-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2016.09.005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151899"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0101"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2009.10.004"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817700593"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131709600319"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.004"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9747-3"},{"key":"e_1_2_7_33_1","unstructured":"SEER.SEERICD\u2010O\u20103coding materials.https:\/\/seer.cancer.gov\/icd\u2010o\u20103\/. Accessed September 13 2017."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90133-8"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.02.010"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29191"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24608"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28413"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21584"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22788"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2016.09.005"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30212"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25212"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.09.012"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.08.046"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01690-X"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.11.034"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3595"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599818758020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599818758020","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599818758020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:36:19Z","timestamp":1760967379000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599818758020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,20]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1177\/0194599818758020"],"URL":"https:\/\/doi.org\/10.1177\/0194599818758020","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,20]]},"assertion":[{"value":"2017-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}