{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:31:08Z","timestamp":1773448268337,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Surgical repair of a tympanic membrane perforation is a common otologic procedure. However, achieving a successful closure can be challenging, especially if the anterior margin of the tympanic membrane is involved. The aim of this study was to systematically review the literature on evidence published in closure of anterior tympanic membrane perforations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>The following data sources were searched: Cochrane Central Register of Controlled Trials (1997 to August, 3 2017), MEDLINE (February 1948 to August 3, 2017), and Embase (1975 to August 3, 2017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Extraction<\/jats:title><jats:p>Two authors independently reviewed titles and abstracts. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses) guidelines were followed. For the purpose of this study, the inclusion criteria were as follows; (1) studies reporting surgical technique for closure of anterior tympanic membrane perforations, (2) primary cases only, (3) articles published in the English language, (4) minimum 6\u2010month follow\u2010up, and (5) recorded pre\u2010 and postoperative audiometry. The exclusion criteria were non\u2013English language articles, revision surgery, and no audiometric outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On initial search, a total of 181 articles were identified (PubMed, n = 136; Cochrane, n = 28; Embase, n = 17). Based on the criteria, 136 articles were excluded. Full text of 45 articles was reviewed, and a further 24 articles were excluded. A total of 21 articles fulfilled the criteria for study inclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All published evidence is level 4. High\u2010quality controlled studies are required to determine the most effective method for closure of anterior tympanic membrane perforation.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818764335","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T12:54:00Z","timestamp":1520945640000},"page":"1011-1015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Achieving a Successful Closure of an Anterior Tympanic Membrane Perforation: Evidence\u2010Based Systematic Review"],"prefix":"10.1002","volume":"158","author":[{"given":"Vikranth","family":"Visvanathan","sequence":"first","affiliation":[{"name":"University Hospitals North Midlands NHS Trust Stoke\u2010on\u2010Trent England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vamsidhar","family":"Vallamkondu","sequence":"additional","affiliation":[{"name":"Department of ENT\u2013Head and Neck Surgery Aberdeen Royal 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