{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:21:23Z","timestamp":1783419683243,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the adverse events and time to diagnosis of in\u2010office laryngeal biopsy (IOB) procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Outpatient clinic\u2013tertiary referral medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 390 IOBs were included in this study. Data on demographic characteristics, outcomes, and complications were collected. Complications were classified as severe\u2014necessitating further intervention or admission\u2014or mild and self\u2010limited. Delay in diagnosis, assessed as a complication of IOB, was calculated as the time from initial examination to final diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 390 IOBs, 4 (1%) had complications: epistaxis (n = 2), vocal fold hematoma (n = 1), and aspiration event (n = 1). There were no reports of complications at follow\u2010up. The sensitivity of IOB versus direct laryngoscopy biopsies was 77.8%, and the specificity was 95.1%. When the IOB showed malignancy as a final diagnosis, time to diagnosis was 10.7\u00a0days (95% CI, 8.6\u201012.8). When IOB pathology results changed from benign or carcinoma in situ to malignant (squamous cell carcinoma) by direct laryngoscopy, time to diagnosis was longer: 49.1\u00a0days (95% CI, 38.1\u201060.1) and 36.1\u00a0days (95% CI, 15.1\u201057.1; <jats:italic>P<\/jats:italic> &lt;. 05), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cohort, IOBs appear to be free of significant adverse events. IOBs for suspicious laryngeal lesions shorten the time to diagnosis and treatment for the majority of patients; the minority showed a small and insignificant delay.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818764412","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T13:02:15Z","timestamp":1520946135000},"page":"97-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Adverse Events and Time to Diagnosis of In\u2010Office Laryngeal Biopsy Procedures"],"prefix":"10.1002","volume":"159","author":[{"given":"Jacob T.","family":"Cohen","sequence":"first","affiliation":[{"name":"Head and Neck Center Department of Otolaryngology\u2013Head and Neck Surgery Rambam Medical Center Haifa Israel"},{"name":"Laboratory for Applied Cancer Research Rambam Healthcare Campus Rappaport Institute of Medicine and Research Technion\u2013Israel Institute of Technology Haifa 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