{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:38:10Z","timestamp":1791221890268,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the therapeutic value of sulodexide monotherapy in the management of patients with chronic subjective idiopathic tinnitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Randomized double\u2010blinded controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single tertiary care institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Observations from 124 patients who received either sulodexide or placebo were collected from the patients\u2019 medical records. Computer\u2010generated tables were used to allocate treatments. Patients took 1 tablet of the drug or placebo each morning and evening for 40 consecutive days. The response was assessed by the Tinnitus Handicap Inventory and the Mini\u2010Tinnitus Questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2014 and 2017, 124 patients were divided into 2 treatment arms. The sulodexide group encompassed 63 patients, whereas the placebo arm contained 61 patients. Tinnitus Handicap Inventory and Mini\u2010Tinnitus Questionnaire scores were more decreased in the sulodexide arm compared to the placebo group (<jats:italic>P<\/jats:italic> =. 03 and <jats:italic>P<\/jats:italic> &lt;. 01, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sulodexide monotherapy decreases chronic subjective idiopathic tinnitus.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818767618","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T04:07:28Z","timestamp":1525147648000},"page":"1107-1112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"158","author":[{"given":"Marc","family":"El Beaino","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Saint Joseph University Hotel Dieu de France Hospital Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan K.","family":"McCaskey","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Texas Medical Branch Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Eter","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Saint Joseph University Hotel Dieu de France Hospital Beirut 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