{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:52:43Z","timestamp":1768701163411,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T00:00:00Z","timestamp":1522713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Immune checkpoint inhibition used in combination with standard cisplatin\u2010based chemotherapy regimens is currently under evaluation in clinical trials for head and neck squamous cell carcinoma (HNSCC). The impact of anti\u2013PD\u20101 therapy on cisplatin\u2010induced ototoxicity and nephrotoxicity has not been established. Here we use a murine model of cisplatin\u2010induced hearing loss to investigate the impact of anti\u2013PD\u20101 immunotherapy on auditory brainstem responses (ABRs), distortion product otoacoustic emissions (DPOAEs), serum creatinine, and hair cell and renal histology. We demonstrate only mild worsening of DPOAEs at 14.4 and 16\u00a0kHz as well as a mild increase in serum creatinine. Renal and hair cell histology as well as ABR measures were unchanged by PD\u20101\u00a0inhibition. Thus, our data suggest that the use of PD\u20101\u00a0inhibition in conjunction with cisplatin results in toxicities that are similar to those of cisplatin alone.<\/jats:p>","DOI":"10.1177\/0194599818767621","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T04:00:55Z","timestamp":1522728055000},"page":"343-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["PD\u20101 Inhibition Minimally Affects Cisplatin\u2010Induced Toxicities in a Murine Model"],"prefix":"10.1002","volume":"159","author":[{"given":"Katie","family":"Spielbauer","sequence":"first","affiliation":[{"name":"Section on Sensory Cell Biology National Institute on Deafness and Other Communication Disorders National Institutes of Health Bethesda Maryland USA"},{"name":"Medical Research Scholars Program National Institutes of Health Bethesda Maryland USA"},{"name":"Michigan State University College of Human Medicine East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Section on Sensory Cell Biology National Institute on Deafness and Other Communication Disorders National Institutes of Health Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Integrative Therapeutics Program National Institute on Deafness and Other Communication Disorders National Institutes of Health Bethesda Maryland USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins University Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602252"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30066-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2016-000122"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.2.257"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.4.574"},{"key":"e_1_2_8_8_1","first-page":"19","article-title":"Ototoxicity in patients receiving cisplatin: importance of dose and method of drug administration","volume":"66","author":"Reddel RR","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71353"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5138-14.2015"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01837-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0881"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0235"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599818767621","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599818767621","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599818767621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:36:39Z","timestamp":1760967399000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599818767621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,3]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1177\/0194599818767621"],"URL":"https:\/\/doi.org\/10.1177\/0194599818767621","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,3]]},"assertion":[{"value":"2018-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}