{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:49:35Z","timestamp":1767998975130,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to evaluate the relationship between nasal eosinophilia and nasal hyperresponsiveness to allergen extract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic tertiary rhinologic practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We performed allergy tests (skin prick test and multiple allergosorbent test) and nasal cytology for 194 patients with rhinitis symptoms (76\u00a0males and 118 females; age, 11\u201069 years). According to the results, they were classified into 4\u00a0groups: group A (allergic rhinitis with eosinophilia, n = 26), group B (allergic rhinitis without eosinophilia, n = 77), group C (nonallergic rhinitis with eosinophilia syndrome, n = 20), and group D (nonallergic rhinitis without eosinophilia, n = 71). We performed a nasal provocation test (NPT) using house dust mite extract and assessed the changes in symptoms and the decrease in acoustic parameters (total nasal volume and minimal cross\u2010sectional area [MCA]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in group C were more likely to have severe rhinorrhea and sneezing than those in group D (<jats:italic>P<\/jats:italic> &lt;. 001). After NPT, group C had greater aggravation of nasal obstruction than group D (<jats:italic>P<\/jats:italic> &lt;. 001). Group C also showed markedly greater MCA changes as compared with group D 15\u00a0minutes after the antigen challenge (<jats:italic>P<\/jats:italic> =. 002). There was significant correlation between the number of eosinophils and an increase in nasal obstruction (<jats:italic>r<\/jats:italic> = 0.319, <jats:italic>P<\/jats:italic> =. 0009), rhinorrhea (<jats:italic>r<\/jats:italic> = 0.302, <jats:italic>P<\/jats:italic> =. 0017), sneezing (<jats:italic>r<\/jats:italic> = 0.219, <jats:italic>P<\/jats:italic> =. 0241), change in the total nasal volume 15\u00a0minutes after NPT (<jats:italic>r<\/jats:italic> = 0.287, <jats:italic>P<\/jats:italic> =. 0028), and change in the MCA 15\u00a0minutes (<jats:italic>r<\/jats:italic> = 0.322, <jats:italic>P<\/jats:italic> =. 0008) and 30\u00a0minutes (<jats:italic>r<\/jats:italic> = 0.250, <jats:italic>P<\/jats:italic> =. 0098) after NPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with NAR, nasal eosinophilia is associated with provocative response after NPT. Further research should be performed to elucidate the mechanisms that underlie this phenomenon.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818768806","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T04:02:45Z","timestamp":1523937765000},"page":"231-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Correlation of Nasal Eosinophilia and Response after Nasal Provocation Test in Patients with Nonallergic Rhinitis"],"prefix":"10.1002","volume":"159","author":[{"given":"Ki\u2010Ik","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery College of Medicine Inha University Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery College of Medicine Inha University Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Chan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery College of Medicine Inha University Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Sun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery College of Medicine Inha University Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Hyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery College of Medicine Inha University Incheon Republic of 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