{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:59:35Z","timestamp":1784185175842,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) Compare lateral skull base (LSB) height\/thickness in patients with spontaneous cerebrospinal fluid otorrhea (CSF), superior canal dehiscence (SCD), acoustic neuromas (AN), and otosclerosis (OTO). (2) Perform correlations between age, body mass index (BMI), sex, and LSB height\/thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Patients with CSF, SCD, AN, and OTO diagnosed from 2006 to 2016 were included if they had high\u2010definition temporal bone computed tomography (CT) and absence of trauma, radiation, chronic ear disease, and\/or congenital anomaly. CT\u2010based measurements included LSB height\/thickness and pneumatization rates overlaying the external auditory canal (EAC), tegmen tympani (TgT), perigeniculate region (PG), and internal auditory canal (IAC). LSB height\/thickness, age, sex, and BMI were statistically correlated. In total, 256 patients and 493 ears (109 CSF, 115 SCD, 269\u00a0AN\/OTO) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with CSF had significantly higher BMIs than the other groups (<jats:italic>P<\/jats:italic> &lt;. 001). Patients with CSF and SCD had similar radiographic LSB phenotypes at most measured locations. Both groups exhibited a significantly lower LSB height compared to the AN and OTO groups (mean, 3.9\u20104.2\u00a0mm vs 4.9\u20105.6\u00a0mm; <jats:italic>P<\/jats:italic> &lt;. 001). Patients with CSF and SCD also demonstrated significantly lower pneumatization rates, as low as 17% to 23% overlaying the PG and IAC (<jats:italic>P<\/jats:italic> &lt;. 001). There were no statistically significant correlations found between age, sex, BMI, and LSB height\/thickness at any measurement location in any group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with CSF and SCD exhibit similar radiographic LSB phenotypes. Age, sex, and BMI do not significantly correlate with LSB height\/thickness. These data support the theory that CSF and SCD arise via similar congenital pathoetiologic mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818769875","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T16:01:28Z","timestamp":1524585688000},"page":"543-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Are Patients with Spontaneous CSF Otorrhea and Superior Canal Dehiscence Congenitally Predisposed to Their Disorders?"],"prefix":"10.1002","volume":"159","author":[{"given":"Shawn M.","family":"Stevens","sequence":"first","affiliation":[{"name":"Neurotology Otology and Skull Base Surgery Arizona Otolaryngology Consultants and Barrow Neurologic Institute Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiefer","family":"Hock","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine Cincinnati Ohio 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