{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:55:46Z","timestamp":1789656946644,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The absence of a centralized health system has limited epidemiologic research surrounding vestibular schwannoma (VS) in the United States. The Rochester Epidemiology Project (REP) comprises a unique medical consortium that covers a complete population of all ages in a well\u2010defined geographic region over the past half\u2010century. The objective of this study was to characterize the incidence of sporadic VS over this extended period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Population\u2010based study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Olmsted County, Minnesota.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Review of all VSs diagnosed between January 1, 1966, and December 31, 2016, was conducted with the REP medical records linkage system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 153\u00a0incident cases of VS were identified. The incidence of VS significantly increased over the past half\u2010century from 1.5 per 100,000 person\u2010years during the first decade to 4.2\u00a0in the last decade (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;. 001). Incidence increased with age (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;. 001): those aged \u226570 years exhibited the highest incidence rate at 18.3 per 100,000 person\u2010years in the last decade. Age at diagnosis significantly increased from a median of 52 years in the first decade to 62 years in the last (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;. 001). Despite presenting with fewer symptoms and smaller tumors, the time delay between symptom onset and diagnosis significantly decreased over the past 5 decades (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt;. 05). Almost 1\u00a0in 4 patients was diagnosed incidentally in the last decade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of VS increased significantly over the past half\u2010century to a rate greater than previously reported. Patients\u2019 ease of access to medical care in Olmsted County and the comprehensive REP system likely contributed to this elevated detection rate of VS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599818770629","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T04:29:42Z","timestamp":1525148982000},"page":"717-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":150,"title":["Incidence of Vestibular Schwannoma over the Past Half\u2010Century: A Population\u2010Based Study of Olmsted County, Minnesota"],"prefix":"10.1002","volume":"159","author":[{"given":"John P.","family":"Marinelli","sequence":"first","affiliation":[{"name":"School of Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Lohse","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic Rochester Minnesota USA"},{"name":"Department of Neurologic Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b3016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.2.216"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.7.FOCUS12186"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-015-1827-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815590105"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.3.241"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1975.00780310013004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.08.012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys195"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.11.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70101-X"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq482"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-958307"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e3181f22660"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.105716"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599818770629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599818770629","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599818770629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:27:46Z","timestamp":1760970466000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599818770629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1177\/0194599818770629"],"URL":"https:\/\/doi.org\/10.1177\/0194599818770629","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"2018-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}