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This study seeks to combine data across studies to generate a summary measure and explore factors that might lead to variation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>OVID Medline, Scopus, EbscoHost, Database of Abstracts and Reviews of Effects, Health Technology Assessment, and National Health Service Economic Evaluation Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>A search was performed following the PRISMA guidelines. Two independent researchers conducted a search using the mentioned data sources. Studies published before August 29, 2016, that involved ESS to treat CRSwNP were included. Mean changes in Sinonasal Outcome Test\u201322 (SNOT\u201022) scores were determined through metaregression of the following independent variables: publication year, sex, age, allergy status, asthma, tobacco use, prior surgery, follow\u2010up length, and preoperative SNOT\u201022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen articles with 3048 patients treated with ESS met inclusion criteria. Pooled analyses of SNOT\u201022 scores revealed a mean change of 23.0 points (95% CI, 20.2\u201025.8; <jats:italic>P<\/jats:italic> &lt;. 001). A metaregression of patient factor effects on the mean change of SNOT\u201022 scores demonstrated that age (<jats:italic>r =<\/jats:italic> 0.71, <jats:italic>P<\/jats:italic> =. 01), asthma (<jats:italic>r<\/jats:italic> = 0.21, <jats:italic>P<\/jats:italic> =. 01), prior ESS (<jats:italic>r<\/jats:italic> = 0.29, <jats:italic>P<\/jats:italic> =. 01), and preoperative SNOT\u201022 score (<jats:italic>r<\/jats:italic> = 0.4, <jats:italic>P<\/jats:italic> &lt;. 01) correlated with greater improvement in SNOT\u201022 scores. Tobacco use (<jats:italic>r<\/jats:italic> = \u22120.91, <jats:italic>P<\/jats:italic> =. 01) and longer lengths of follow\u2010up (<jats:italic>r<\/jats:italic> = \u22120.45, <jats:italic>P<\/jats:italic> &lt;. 01) were associated with less improvement in SNOT\u201022 scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Quality\u2010of\u2010life outcomes are significantly improved after ESS among patients with CRSwNP. Patient\u2010specific factors may affect the degree of SNOT\u201022 change after surgery.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818773065","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T04:08:19Z","timestamp":1525147699000},"page":"414-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Systematic Review and Meta\u2010analysis of SNOT\u201022 Outcomes after Surgery for Chronic Rhinosinusitis with Nasal Polyposis"],"prefix":"10.1002","volume":"159","author":[{"given":"Phong T.","family":"Le","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabun","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Mattos","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery School of Medicine University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24040"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21664"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24916"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/108854196778662246"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318058197a"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2007.01.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_8_13_1","unstructured":"National Heart Lung and Blood Institute.National Institute of Health study quality assessment tool.https:\/\/www.nhlbi.nih.gov\/health\u2010pro\/guidelines\/in\u2010develop\/cardiovascular\u2010risk\u2010reduction\/tools. 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