{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:03:32Z","timestamp":1785297812557,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We sought to determine whether chronic rhinosinusitis (CRS) symptom severity, endoscopic exam findings, and acute exacerbation of CRS (AECRS) frequency\u2014all important and distinct clinical manifestations of CRS\u2014would be predictive of each other and, therefore, inform when further assessment of each other metric should be pursued.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary academic rhinology clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>In total, 241 patients with CRS were prospectively recruited and completed the 22\u2010item Sinonasal Outcome Test (SNOT\u201022) to reflect CRS symptom severity. AECRS frequency was assessed using the number of sinus infections as well as CRS\u2010related antibiotics and CRS\u2010related oral corticosteroids used in the past 3\u00a0months. An endoscopy score was calculated for each patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SNOT\u201022 score and AECRS were predictive of each other while AECRS and endoscopy score were not predictive of each other. SNOT\u201022 score could be used to predict having had, in the past 3\u00a0months, at least 1 sinus infection (area under the curve [AUC] = 0.727; <jats:italic>P<\/jats:italic> &lt;. 001), at least 1 CRS\u2010related antibiotic used (AUC = 0.691; <jats:italic>P<\/jats:italic> &lt;. 001), or at least 1 CRS\u2010related oral corticosteroid course used (AUC = 0.655; <jats:italic>P<\/jats:italic> &lt;. 001). Having a SNOT\u201022 score \u226530 could be predicted by reporting at least 1 sinus infection (AUC = 0.634; <jats:italic>P<\/jats:italic> &lt;. 001), CRS\u2010related antibiotics (AUC = 0.614; <jats:italic>P<\/jats:italic> &lt;. 001), or CRS\u2010related oral corticosteroids (AUC = 0.616; <jats:italic>P<\/jats:italic> &lt;. 001) in the past 3\u00a0months. These relationships held for patients with and without nasal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The predictive power of CRS outcome measures reflecting symptomatology, AECRS frequency, and endoscopic findings may be of clinical utility in situations where time or resources are limited to perform an ideally full assessment of patients with CRS.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818774741","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T04:29:10Z","timestamp":1526358550000},"page":"766-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Reciprocal Predictive Accuracy of Sinonasal Symptom Severity, Nasal Endoscopy, and Frequency of Past Chronic Rhinosinusitis Exacerbations"],"prefix":"10.1002","volume":"159","author":[{"given":"Marlene M.","family":"Speth","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Hals\u2010, Nasen\u2010, Ohren\u2010Krankheiten, Hals\u2010und Gesichtschirurgie Kantonsspital Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Gaudin","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Mund\u2010 Kiefer\u2010 und Gesichtschirurgie Universit\u00e4tsmedizin Charit Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd P.","family":"Hoehle","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Caradonna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts USA"},{"name":"Division of Otolaryngology Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey T.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts USA"},{"name":"Division of 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