{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:07:21Z","timestamp":1789110441650,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assist otolaryngologists in counseling patients with hoarseness who would benefit from injection laryngoplasty on whether or not to perform the procedure in the office vs the operating room.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Cochrane library, CINAHL, PubMed, and EMBASE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Systematic review using Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis (PRISMA) reporting standards of English\u2010language articles that compared voice outcomes for in\u2010office and in the operating room injection laryngoplasty. Two independent investigators assessed study eligibility, rated the quality using Methodological Index for Non\u2010Randomized Studies (MINORS), and abstracted data for comparative analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 689\u00a0initial studies, 4 observational, comparative studies met inclusion criteria, with follow\u2010up of 2 weeks to 12\u00a0months postinjection. Laryngoplasty was most commonly performed for vocal fold immobility with varied injectable materials (micronized dermis, hyaluronic acid, and calcium hydroxyapatite). Follow\u2010up ranged from 2 weeks to 12\u00a0months. Voice outcomes improved in all studies, with comparable improvement for patients injected in the office vs the operating room (<jats:italic>P<\/jats:italic> =. 42 to <jats:italic>P<\/jats:italic> =. 88). Meta\u2010analysis of 3 studies showed no difference in Voice Handicap Index\u201310 voice outcomes by treatment setting (standardized mean difference \u22120.11, <jats:italic>P<\/jats:italic> =. 441), with the 95% confidence interval (\u20130.405 to 0.176), making it unlikely that anything larger than a small or trivial difference was missed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our systematic review makes it unlikely that meaningful clinical differences exist in postprocedure voice outcomes for injection laryngoplasty in the office vs the operating room.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818780207","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T12:23:23Z","timestamp":1531225403000},"page":"608-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Systematic Review of Voice Outcomes for Injection Laryngoplasty Performed under Local vs General Anesthesia"],"prefix":"10.1002","volume":"159","author":[{"given":"Daniel P.","family":"Ballard","sequence":"first","affiliation":[{"name":"State University of New York Downstate Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Abramowitz","sequence":"additional","affiliation":[{"name":"State University of New York Downstate Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Sukato","sequence":"additional","affiliation":[{"name":"State University of New York Downstate Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Bentsianov","sequence":"additional","affiliation":[{"name":"State University of New York Downstate Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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