{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:18:20Z","timestamp":1770149900780,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013762","name":"Aurora Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Evaluate serum C\u2010reactive protein (CRP) in human papillomavirus (HPV)\u2013positive oropharynx cancer as compared with HPV\u2010negative oropharynx cancer and determine if CRP levels were associated with overall survival and\/or recurrence\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care academic cancer center between 2007 and 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Among patients with oropharynx cancer and confirmed HPV status, plasma CRP levels were measured with a high\u2010sensitivity ELISA kit. Multivariable logistic regression analysis compared 4 categories of CRP (low, moderate, high, very high) between the HPV\u2010positive and HPV\u2010negative groups. Kaplan\u2010Meier methods and Cox regression models were used to determine overall survival and recurrence\u2010free survival by CRP level in both populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 113 HPV\u2010positive and 110 HPV\u2010negative patients, CRP levels were significantly higher in the HPV\u2010positive group, but these levels did not demonstrate a statistically significant dose\u2010response trend. Higher CRP levels were also associated with reduced overall survival (<jats:italic>P<\/jats:italic> =. 016) and recurrence\u2010free survival (<jats:italic>P<\/jats:italic> &lt;. 001) within the HPV\u2010negative group in univariable analysis; in multivariate analysis, the comparisons were not significantly different. Within HPV\u2010positive oropharynx cancer, CRP levels were not significantly associated with overall survival or recurrence\u2010free survival in univariable or multivariable analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circulating CRP was higher in HPV\u2010positive versus HPV\u2010negative oropharynx cancer. Among HPV\u2010negative patients, higher CRP levels were associated with reduced survival.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818800297","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T13:55:46Z","timestamp":1537278946000},"page":"494-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["C\u2010reactive Protein in HPV\u2010Positive and HPV\u2010Negative Oropharyngeal Cancer"],"prefix":"10.1002","volume":"160","author":[{"given":"Stephanie","family":"Johnson\u2010Obaseki","sequence":"first","affiliation":[{"name":"University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Caulley","sequence":"additional","affiliation":[{"name":"University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Corsten","sequence":"additional","affiliation":[{"name":"Aurora Heathcare Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Dimitroulakos","sequence":"additional","affiliation":[{"name":"University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Goldstein","sequence":"additional","affiliation":[{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Irish","sequence":"additional","affiliation":[{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Rider","sequence":"additional","affiliation":[{"name":"Harvard University Cambridge Massachusetts USA"},{"name":"Boston University Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/18715281113129990053"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2050"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351456"},{"key":"e_1_2_7_7_1","first-page":"123","article-title":"Why cancer and inflammation?","volume":"79","author":"Rakoff\u2010Nahoum S","year":"2006","journal-title":"Yale J Biol Med"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp127"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181e64bb1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28211"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0324"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S70954"},{"key":"e_1_2_7_13_1","first-page":"10633","article-title":"Association between serum C\u2010reactive protein value and prognosis of patients with non\u2013small cell lung cancer: a meta\u2010analysis","volume":"8","author":"Jing X","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.0454"},{"key":"e_1_2_7_15_1","first-page":"2259","article-title":"Association of C\u2010reactive protein (CRP) gene polymorphisms, serum CRP levels and cervical cancer prognosis","volume":"31","author":"Polterauer S","year":"2011","journal-title":"Anticancer Res"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-1024"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-015-0656-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-012-0330-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2011.599831"},{"key":"e_1_2_7_20_1","unstructured":"FerleyJ SoerjomataramI ErvikM et al.Cancer incidence and mortality worldwide: IARC CancerBase No. 11.http:\/\/globocan.iarc.fr. 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