{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:20:44Z","timestamp":1767925244330,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of minor structural alterations (MSA) in the vocal fold cover in a population submitted to extralaryngeal site surgery and to characterize them according to morphological and epidemiological parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This was a cross\u2010sectional and observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 147 patients underwent general anesthesia for extralaryngeal site surgery indicated for a procedure extraneous to the study and irrespective of the presence of vocal complaint. Next, detection and morphological characterization of MSAs in the vocal fold cover were performed by means of suspension microlaryngoscopy with laryngeal inspection and palpation without surgical intervention related to this procedure. The laryngeal findings were compared with variables from a clinical and demographic characteristics questionnaire given to these individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 21.1% prevalence of MSAs was identified in the sample, which included a majority of individuals without vocal complaint (95.9%). Of these, 5.4% of individuals had laryngeal microdiaphragms, 16.3% sulcus vocalis, and 4.1% epidermoid cysts. No pouch sulcus or mucosal bridges were found. The identification of these alterations occurred mainly after 10 years of age, without effects of sex, vocal abuse, or upper airway conditions. The most common combination of MSAs was bilateral sulcus vocalis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of MSAs in laryngeal coverage in this predominantly vocally asymptomatic population was 21.1%, with identification of sulcus vocalis, epidermoid cyst, and laryngeal microdiaphragm. Age was the only clinical or demographic characteristic associated with these alterations.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818804768","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T13:21:41Z","timestamp":1540300901000},"page":"295-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of Minor Larynx Structural Alterations: Influence on the Concept of a Normal Vocal Fold"],"prefix":"10.1002","volume":"160","author":[{"given":"Bruno Teixeira","family":"Moraes","sequence":"first","affiliation":[{"name":"Department of Surgery Federal University of Pernambuco Recife\/PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi Grigoletto","family":"De Biase","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Federal University of S\u00e3o Paulo S\u00e3o Paulo\/SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"215","article-title":"Stimmst\u00f6rungen infolge im Kehlkopfspiegel sichtbarer Asymmetrien der Stimmlippen","volume":"2","author":"Reker H","year":"1938","journal-title":"Arch Sprach Stimmheilk"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195802000-00006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198509000-00014"},{"key":"e_1_2_9_5_1","first-page":"2","article-title":"Minor structural alterations of the larynx MSA: basic considerations","volume":"13","author":"Pontes P","year":"1994","journal-title":"Acta AWHO"},{"key":"e_1_2_9_6_1","first-page":"333","article-title":"Sulcus glottides","volume":"102","author":"Roch JB","year":"1981","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610500304"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050000254"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811404639"},{"key":"e_1_2_9_10_1","first-page":"911","article-title":"Clinical observations in the sulcus vocalis","volume":"70","author":"Ishii H","year":"1967","journal-title":"J Otolaryngol"},{"key":"e_1_2_9_11_1","first-page":"819","article-title":"Clinical and pathological investigations of sulcus vocalis","volume":"22","author":"Shin Y","year":"1976","journal-title":"Otologia (Fukuoka)"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2014.05.019"},{"key":"e_1_2_9_13_1","first-page":"446","article-title":"Microsurgery for benign lesions of the vocal folds","volume":"67","author":"Bouchayer M","year":"1988","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00112-1"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"1","article-title":"Vocal fold cover minor structural alterations in children","volume":"6","author":"De Melo EC","year":"2002","journal-title":"Int Arch Otorhinolaryngol"},{"key":"e_1_2_9_16_1","first-page":"480","article-title":"Disfonia cr\u00f4nica na inf\u00e2ncia e adolesc\u00eancia: estudo retrospectivo","volume":"66","author":"Freitas MR","year":"2000","journal-title":"Rev Bras Otorrinolaringol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010901112"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150685.54893.e9"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000505"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2010.10.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700111"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2009.03.007"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199401000-00005"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130608501004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300708"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000263771"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(83)80002-9"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900901"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480802579058"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599818804768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599818804768","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599818804768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:34:13Z","timestamp":1760963653000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599818804768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,23]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1177\/0194599818804768"],"URL":"https:\/\/doi.org\/10.1177\/0194599818804768","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,23]]},"assertion":[{"value":"2018-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}