{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:57:57Z","timestamp":1780757877613,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the dental class occlusion and lateral cephalometry of children with conservatively treated Pierre Robin sequence (PRS) and to identify associations between these findings and prepalatoplasty cleft palate measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Among 22 patients with PRS, the following data were prospectively collected: demographics and preoperative cleft palate measurements. After patients reached age 6 years, an orthodontist assessed dental occlusion class and performed a lateral cephalometric analysis. PRS cephalometric data were compared with reference population values. Bivariate logistic regression was used to test the association with malocclusion class. Results are presented as odds ratios with 95% profile likelihood confidence intervals. The association between cleft measurements and cephalometric parameters was tested with Spearman's correlation (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 22 patients had bimaxillary hypoplasia and were prone to hyperdivergency, with a 41% rate of dental class III malocclusion. An increased anterior growth of the still retrusive mandible mostly accounts for the occurrence of the class III malocclusion in PRS (class II SNB = 74.3\u00b0 vs class III SNB = 77.6\u00b0, <jats:italic>P<\/jats:italic> =. 04). A larger cleft at the time of the cleft repair (mean, 11\u00a0months) was associated with increased mandibular retrusion (smaller SNB angle, <jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = \u22120.5, <jats:italic>P<\/jats:italic> =. 02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 41% rate of class III malocclusion among these conservatively treated patients needs to be considered in the choice of the initial airway approach. The future impact of early mandibular advancement will have to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818807918","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T13:00:24Z","timestamp":1539694824000},"page":"246-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cleft Palates and Occlusal Outcomes in Pierre Robin Sequence"],"prefix":"10.1002","volume":"160","author":[{"given":"Julie Bao Anh","family":"Do","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Universit\u00e9 Laval Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Bellerive","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universit\u00e9 Laval Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Sophie","family":"Julien","sequence":"additional","affiliation":[{"name":"Clinical Research Platform CHU de Qu\u00e9bec\u2013Universit\u00e9 Laval Research Centre Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques E.","family":"Leclerc","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Centre Hospitalier Universitaire de Qu\u00e9bec Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2615"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.01.035"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311407"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002721"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.03.033"},{"key":"e_1_2_9_7_1","first-page":"207","article-title":"Tracheotomy versus mandibular distraction osteogenesis in Canadian children with Pierre Robin sequence: a comparative cost analysis","volume":"41","author":"Hong P","year":"2012","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2001.115038"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.06.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2008.07.020"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1991)028<0425:MTAAIP>2.3.CO;2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199404001-00006"},{"key":"e_1_2_9_14_1","first-page":"30","volume-title":"What Is Cleft Lip and Palate? A Multidisciplinary Update","author":"Kriens O"},{"key":"e_1_2_9_15_1","first-page":"413","article-title":"Can we predict a difficult intubation in cleft lip\/palate patients?","volume":"40","author":"Arteau\u2010Gauthier I","year":"2011","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1597\/12-261"},{"key":"e_1_2_9_17_1","first-page":"107","volume-title":"Maxillofacial Trauma","author":"Wilson K"},{"key":"e_1_2_9_18_1","first-page":"89","volume":"29","author":"Mesures c\u00e9phalom\u00e9triques","year":"1992","journal-title":"Journal dentaire du Qu\u00e9bec"},{"key":"e_1_2_9_19_1","first-page":"898","article-title":"Skeletal characteristics and treatment outcome of five patients with Robin sequence","volume":"76","author":"Matsuda A","year":"2006","journal-title":"Angle Orthod"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1597\/09-154"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001250305"},{"key":"e_1_2_9_22_1","first-page":"299","volume-title":"The Biological Mechanisms of Tooth Movement and Craniofacial Adaptation","author":"Lavrin IG"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e318031d8a1"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599818807918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599818807918","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599818807918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:33:59Z","timestamp":1760963639000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599818807918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1177\/0194599818807918"],"URL":"https:\/\/doi.org\/10.1177\/0194599818807918","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,16]]},"assertion":[{"value":"2018-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}