{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:30:32Z","timestamp":1761006632204,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005193","name":"American Academy of Otolaryngology-Head and Neck Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001117"],"award-info":[{"award-number":["UL1TR001117"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ULI RR033183","KL2 RR0333182"],"award-info":[{"award-number":["ULI RR033183","KL2 RR0333182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the relationship between community\u2010acquired pneumonia (CAP) and proton pump inhibitor (PPI) treatment among patients with laryngeal\/voice disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Large national administrative US claims database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Patients were included if they were \u226518 years old; had outpatient treatment for a laryngeal\/voice disorder from January 1, 2010, to December 31, 2014 (per <jats:italic>International Classification of Diseases, Ninth Revision, Clinical Modification<\/jats:italic> codes); had 12\u00a0months of continuous enrollment prior to the index date (ie, first diagnosis of laryngeal\/voice disorder); had no preindex diagnosis of CAP; and had prescription claims captured from 1 year preindex to end of follow\u2010up. Patient demographics, comorbid conditions, index laryngeal diagnosis, number of unique preindex patient encounters, and CAP diagnoses during the postindex 3 years were collected. Two models\u2014a time\u2010dependent Cox regression model and a propensity score\u2013based approach with a marginal structural model\u2014were separately performed for patients with and without pre\u2013index date PPI prescriptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 392,355 unique patients met inclusion criteria; 188,128 (47.9%) had a PPI prescription. The 3\u2010year absolute risk for CAP was 4.0% and 5.3% among patients without and with preindex PPI use, respectively. For patients without and with pre\u2013index date PPI use, the CAP occurrence for a person who had already received a PPI is 30% to 50% higher, respectively, than for a person who had not yet had a PPI but may receive one later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients without and with pre\u2013index date PPI use experienced a roughly 30% to 50% increased likelihood of CAP, respectively, as compared with patients who had not had PPI prescriptions.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599818811292","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T04:42:16Z","timestamp":1542084136000},"page":"519-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Associations between Community\u2010Acquired Pneumonia and Proton Pump Inhibitors in the Laryngeal\/Voice\u2010Disordered 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of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Misono","sequence":"additional","affiliation":[{"name":"Lions Voice Clinic Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota 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