{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:27:27Z","timestamp":1792621647201,"version":"4.5.0"},"reference-count":158,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To review the current literature about the epidemiology, clinical presentation, diagnosis, and treatment of laryngopharyngeal reflux (LPR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed, Cochrane Library, and Scopus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive review of the literature on LPR epidemiology, clinical presentation, diagnosis, and treatment was conducted. Using the PRISMA statement, 3 authors selected relevant publications to provide a critical analysis of the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The important heterogeneity across studies in LPR diagnosis continues to make it difficult to summarize a single body of thought. Controversies persist concerning epidemiology, clinical presentation, diagnosis, and treatment. No recent epidemiologic study exists regarding prevalence and incidence with the use of objective diagnostic tools. There is no survey that evaluates the prevalence of symptoms and signs on a large number of patients with confirmed LPR. Regarding diagnosis, an increasing number of authors used multichannel intraluminal impedance\u2013pH monitoring, although there is no consensus regarding standardization of the diagnostic criteria. The efficiency of proton pump inhibitor (PPI) therapy remains poorly demonstrated and misevaluated by incomplete clinical tools that do not take into consideration many symptoms and extralaryngeal findings. Despite the recent advances in knowledge about nonacid LPR, treatment protocols based on PPIs do not seem to have evolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for Practice<\/jats:title>\n                    <jats:p>The development of multichannel intraluminal impedance\u2013pH monitoring and pepsin and bile salt detection should be considered for the establishment of a multiparameter diagnostic approach. LPR treatment should evolve to a more personalized regimen, including diet, PPIs, alginate, and magaldrate according to individual patient characteristics. Multicenter international studies with a standardized protocol could improve scientific knowledge about LPR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599819827488","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T18:42:25Z","timestamp":1549996945000},"page":"762-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":351,"title":["Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review"],"prefix":"10.1002","volume":"160","author":[{"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists International Federation of Oto\u2010rhino\u2010laryngological Societies Paris France"},{"name":"Department of Anatomy and Experimental Oncology Mons School of Medicine UMONS Research Institute for Health Sciences and Technology University of Mons Mons Belgium"},{"name":"Laboratory of Phonetics Faculty of Psychology Research Institute for Language Sciences and Technology University of Mons Mons Belgium"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Faculty of Medicine University Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee M.","family":"Akst","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Latif","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists International Federation of Oto\u2010rhino\u2010laryngological Societies Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Schindler","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists International Federation of Oto\u2010rhino\u2010laryngological Societies Paris France"},{"name":"Department of Biomedical and Clinical Sciences Phoniatric Unit L. 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