{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:39:42Z","timestamp":1784227182940,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The current guidelines recommend that potassium iodide be given in the immediate preoperative period for patients with Graves\u2019 disease who are undergoing thyroidectomy. Nonetheless, the evidence behind this recommendation is tenuous. The purpose of this study is to clarify the benefits of preoperative iodine administration from published comparative studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>We searched PubMed, Embase, Cochrane, and CINAHL from 1980 to June 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Studies were included that compared preoperative iodine administration and no premedication before thyroidectomy. For the meta\u2010analysis, studies were pooled with the random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 510 patients were divided into the iodine (n = 223) and control (n = 287) groups from 9 selected studies. Preoperative iodine administration was significantly associated with decreased thyroid vascularity and intraoperative blood loss. Significant heterogeneity was present among studies. We found no significant difference in thyroid volume or operative time. Furthermore, the meta\u2010analysis showed no difference in the risk of postoperative complications, including vocal cord palsy, hypoparathyroidism\/hypocalcemia, and hemorrhage or hematoma after thyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preoperative iodine administration decreases thyroid vascularity and intraoperative blood loss. Nonetheless, it does not translate to more clinically meaningful differences in terms of operative time and postoperative complications.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599819829052","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T14:09:53Z","timestamp":1549375793000},"page":"993-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of Preoperative Iodine Administration on Thyroidectomy for Hyperthyroidism: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"160","author":[{"given":"Chung\u2010Hsin","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Surgery MacKay Memorial Hospital and Mackay Medical College Taipei Taiwan"},{"name":"Mackay Junior College of Medicine Nursing, and Management Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Sheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery MacKay Memorial Hospital and Mackay Medical College Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie\u2010Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery MacKay Memorial Hospital and Mackay Medical College Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsang\u2010Pai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery MacKay Memorial Hospital and Mackay Medical College Taipei Taiwan"},{"name":"Mackay Junior College of Medicine Nursing, and Management Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Yu","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Surgery MacKay Memorial Hospital and Mackay Medical College 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