{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:18:28Z","timestamp":1792819108595,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the long\u2010term efficacy and potential predictors of uvulopalatopharyngoplasty (UPPP) among adult patients with obstructive sleep apnea (OSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>A systematic search was conducted through PubMed\/Medline, Embase, Web of Science, and the Cochrane Library until December 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Full\u2010text articles were selected that studied adult patients who underwent single\u2010level UPPP or its modification for OSA and had a long\u2010term follow\u2010up (at least 34\u00a0months) with objective sleep study results. Studies that had no objective outcomes or performed other surgical procedures for OSA were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2600 studies, 11 were included. Meta\u2010analysis comparing long\u2010term post\u2010 and preoperative outcomes showed significant improvements, with an 15.4 event\/h (46.1%) decrease of apnea\u2010hypopnea index. Compared with the short\u2010term outcomes (3\u201012\u00a0months), the long\u2010term outcomes were less effective, with apnea\u2010hypopnea index increasing 12.3 events\/h (63.8%) and the surgical response decreasing from 67.3% to 44.35%. Subanalysis of individual patient data showed significant correlations of baseline body mass index, lowest arterial oxygen saturation, and proportion of sleep time with oxygen saturation &lt;90% with long\u2010term surgical response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the surgical efficacy decreasing over time, UPPP and its modification are an effective surgical method for adult OSA in both the short term and the long term after the surgery. Baseline body mass index, lowest arterial oxygen saturation, and proportion of sleep time with oxygen saturation &lt;90% were potentially predictive for long\u2010term surgical response. Case\u2010control studies of the long\u2010term surgical effect of OSA are needed.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599819840356","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T08:27:52Z","timestamp":1560241672000},"page":"401-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Long\u2010term Efficacy of Uvulopalatopharyngoplasty among Adult Patients with Obstructive Sleep Apnea: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"161","author":[{"given":"Mu","family":"He","sequence":"first","affiliation":[{"name":"Department of Otorhinopharyngology\u2013Head and Neck Surgery Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of 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