{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T08:18:07Z","timestamp":1793521087648,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the impact of postoperative paresis on disease\u2010specific quality of life (DSQoL) after thyroidectomy in patients with benign nodular thyroid disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Patients were evaluated before and 3 weeks and 6\u00a0months after surgery in an individual prospective cohort study using videolaryngostroboscopy (VLS), voice range profile, voice handicap index (VHI), multidimensional voice program, maximum phonation time (MPT), and auditory perceptual evaluation. Changes in DSQoL were assessed by the Thyroid\u2010specific Patient\u2010Reported Outcome measure. Cohen\u2019s effect size was used to evaluate changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two patients were included, 55 of whom completed all examinations. Three weeks after surgery, a blinded VLS examination showed signs of paresis of either the recurrent laryngeal nerve or the external branch of the superior laryngeal nerve (RLN\/EBSLN) in 13 patients (24%). A paresis corresponded to a 12 \u00b1 28 point increase in VHI (<jats:italic>P<\/jats:italic> =. 002) and was associated with a significant 4.3 \u00b1 7.5 semitone decrease in the maximum fundamental frequency (<jats:italic>P<\/jats:italic> &lt;. 001) and a 5.3 \u00b1 8.2\u00a0dB reduction in maximum intensity. Further, it was associated with a 4.5 \u00b1 11.2\u00a0second reduction in MPT (<jats:italic>P<\/jats:italic> =. 001) and an increase of 0.40 \u00b1 1.19\u00a0in grade, 0.42 \u00b1 1.41\u00a0in roughness, and 0.36 \u00b1 1.11\u00a0in breathiness. Signs of postoperative RLN\/EBSLN paresis correlated with an 11.0\u2010point (<jats:italic>P<\/jats:italic> =. 02) poorer improvement in goiter symptoms at both 3 weeks and 6\u00a0months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Signs of RLN\/EBSLN paresis after thyroidectomy were associated with less pronounced improvement in goiter symptoms in patients with thyroid nodular disease. However, thyroidectomy was associated with an overall improved DSQoL by 6\u00a0months after surgery.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599819855379","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T08:28:05Z","timestamp":1560241685000},"page":"589-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Impact of Post\u2010thyroidectomy Paresis on Quality of Life in Patients with Nodular Thyroid Disease"],"prefix":"10.1002","volume":"161","author":[{"given":"Jesper Roed","family":"Sorensen","sequence":"first","affiliation":[{"name":"Department of ORL Head &amp; Neck Surgery and Audiology Odense University Hospital Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine","family":"Printz","sequence":"additional","affiliation":[{"name":"Department of ORL Head &amp; Neck Surgery and Audiology Odense University Hospital Odense C 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