{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:51Z","timestamp":1761006951438,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the incidence and significance of asymmetric hypermetabolic laryngeal findings on positron emission tomography\u2013computed tomography (PET\u2010CT) in patients with unilateral true vocal fold (TVF) motion abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single\u2010center tertiary care institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>The medical records of patients with unilateral TVF motion abnormalities were reviewed. The incidence of normal and asymmetric hypermetabolic laryngeal findings was calculated in patients who underwent PET\u2010CT and laryngeal examination, operative laryngoscopy with biopsy, or injection medialization laryngoplasty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 135 patients with unilateral TVF motion abnormalities underwent PET\u2010CT. After exclusion of patients who completed new or surveillance imaging for a laryngeal neoplasm (n = 27), asymmetric hypermetabolic findings in the larynx were noted in 21 (19%) cases: 13 (12%) on the contralateral side of the impaired TVF, 8 (7%) on the ipsilateral side. Two (25%) patients with ipsilateral hypermetabolism had concerning subsequent fiberoptic laryngeal examinations prompting operative biopsy. There was no evidence of inflammatory or neoplastic disease in all patients with contralateral hypermetabolic findings. Fifteen patients completed PET\u2010CT scans after injection medialization procedures; 6 (40%) displayed avidity ipsilateral to the side of the injection. The median time from injection to scan was 27\u00a0days, as opposed to 193\u00a0days in the unremarkable scans (<jats:italic>P<\/jats:italic> =. 011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Contralateral hypermetabolism in patients with unilateral TVF motion abnormalities may represent a false\u2010positive finding. Ipsilateral hypermetabolic uptake without recent fold instrumentation warrants prompt diagnostic evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599819866403","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T13:18:46Z","timestamp":1563887926000},"page":"823-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and Significance of Hypermetabolic PET\u2010CT Findings in Unilateral TVF Motion Impairment"],"prefix":"10.1002","volume":"161","author":[{"given":"Luke","family":"Stanisce","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Cooper University Hospital Camden New Jersey USA"},{"name":"Cooper Medical School at Rowan University Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Renzi","sequence":"additional","affiliation":[{"name":"Cooper Medical School at 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