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Systolic blood pressure (SBP) and diastolic blood pressure were measured at each of 5 study visits from 1987\u20101989 to 2013. Hypertension was defined by elevated systolic or diastolic blood pressure or antihypertensive medication use. A 4\u2010frequency (0.5\u20104\u00a0kHz) better\u2010hearing ear pure tone average in decibels hearing loss (dB HL) was calculated from pure tone audiometry measured in 2013. A cutoff of 40\u00a0dB HL was used to indicate clinically significant moderate to severe hearing impairment. Hearing thresholds at 5 frequencies (0.5\u20108\u00a0kHz) were also considered separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven participants (19%) had hypertension at baseline (1987\u20101989), as opposed to 183 (74%) in 2013. The SBP association with late\u2010life pure tone average differed by the time of measurement, with SBP measured at earlier visits associated with poorer hearing; the difference in pure tone average per 10\u2013mm Hg SBP measured was 1.43\u00a0dB HL (95% CI, 0.32\u20102.53) at baseline versus \u22120.43\u00a0dB HL (95% CI, \u22121.41 to 0.55) in 2013. Baseline hypertension was associated with higher thresholds (poorer hearing) at 4 frequencies (1, 2, 4, 8\u00a0kHz).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Midlife SBP was associated with poorer hearing measured 25 years later. Further analysis into the longitudinal relationship between hypertension and hearing impairment is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599819868145","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T04:00:38Z","timestamp":1565064038000},"page":"996-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Association of Midlife Hypertension with Late\u2010Life Hearing Loss"],"prefix":"10.1002","volume":"161","author":[{"given":"Nicholas S.","family":"Reed","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins School of Medicine Baltimore Maryland USA"},{"name":"Cochlear Center on Hearing and Public Health Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Huddle","sequence":"additional","affiliation":[{"name":"Department of 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Hopkins School of Medicine Baltimore Maryland USA"},{"name":"Cochlear Center on Hearing and Public Health Johns Hopkins University Baltimore Maryland USA"},{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Deal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins School of Medicine Baltimore Maryland USA"},{"name":"Cochlear Center on Hearing and Public Health Johns Hopkins University Baltimore Maryland USA"},{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland 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