{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:57:14Z","timestamp":1790434634559,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T00:00:00Z","timestamp":1570492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the progression of sensorineural hearing loss (SNHL) in the better\u2010 and poorer\u2010hearing ears in children with asymptomatic congenital cytomegalovirus (CMV) infection with isolated SNHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Longitudinal prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We analyzed hearing thresholds of the better\u2010 and poorer\u2010hearing ears of 16 CMV\u2010infected patients with isolated congenital\/early\u2010onset or delayed\u2010onset SNHL identified through hospital\u2010based CMV screening of &gt;30,000\u00a0newborns from 1982 to 1992.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By 12\u00a0months of age, 4 of 7 patients with congenital\/early\u2010onset SNHL developed worsening thresholds in the poorer\u2010hearing ear, and 1 had an improvement in the better\u2010hearing ear. By 18 years of age, all 7 patients had worsening thresholds in the poorer\u2010hearing ear and 3 patients had worsening thresholds in the better\u2010hearing ear. Hearing loss first worsened at a mean age of 2 and 6 years in the poorer\u2010 and better\u2010hearing ears, respectively. Nine patients were diagnosed with delayed\u2010onset SNHL (mean age of 9 years vs 12 years for the poorer\u2010 and better\u2010hearing ears), 6 of whom had worsening thresholds in the poorer\u2010hearing ear and 1\u00a0in both ears.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In most children with congenital CMV infection and isolated SNHL, the poorer\u2010hearing ear worsened earlier and more precipitously than the better\u2010hearing ear. This study suggests that monitoring individual hearing thresholds in both ears is important for appropriate interventions and future evaluation of efficacy of antiviral treatment.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599819880348","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T12:24:55Z","timestamp":1570537495000},"page":"114-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Should You Follow the Better\u2010Hearing Ear for Congenital Cytomegalovirus Infection and Isolated Sensorineural Hearing Loss?"],"prefix":"10.1002","volume":"162","author":[{"given":"Vanessa","family":"Torrecillas","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea 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