{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T09:27:42Z","timestamp":1767173262821,"version":"build-2238731810"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Considering emerging safety concerns involving otic quinolones, we assessed the extent of otic quinolone use for questionable indications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Descriptive cross\u2010sectional study of a national sample of privately insured patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Outpatient encounters in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Children and adults with outpatient pharmacy\u2010dispensing claims for new prescriptions of otic or ophthalmic quinolones in 2017 were identified within the IBM MarketScan Commercial Claims &amp; Encounters and the Medicare Supplemental Database. Each dispensing \u226530\u00a0days apart constituted a unique episode. Only claims with supporting ear\u2010related diagnoses on outpatient encounters \u00b13\u00a0days of dispensing were considered. Ophthalmic drops were excluded if eye\u2010related diagnoses were found \u00b130\u00a0days. Prescribing was classified as appropriate, questionable, or undetermined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found 214,897 episodes in 200,270 patients. Adults were twice as likely as children to have otic treatment with questionable indications (6.2% vs 3.0%). Sensitivity analyses with broader time windows to ascertain diagnoses showed similar proportions of questionable use. Otalgia and cerumen impaction constituted 90% of questionable indications. Family physicians (6.8%) and internists (8.0%) had higher percentages of questionable use than other specialties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on the demonstrated risks of quinolone ear drops, opportunities exist to decrease otic quinolone use, especially in adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599819889607","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T13:46:55Z","timestamp":1574171215000},"page":"102-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Appropriateness of Otic Quinolone Use among Privately Insured US Patients"],"prefix":"10.1002","volume":"162","author":[{"given":"Phuong T.","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida Gainesville Florida USA"},{"name":"Faculty of Pharmacy Ho Chi Minh City University of Technology Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almut G.","family":"Winterstein","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida Gainesville Florida USA"},{"name":"Department of Epidemiology College of Public Health and Health Professions University of Florida Gainesville Florida USA"},{"name":"Center for Drug Evaluation and Safety University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyon","family":"Rhew","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida Gainesville Florida USA"},{"name":"College of Pharmacy Dongduk Women\u2019s University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Safety University of Florida Gainesville Florida USA"},{"name":"Department of Otolaryngology College of Medicine University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-138"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-4060"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.6058"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118949740"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.09.015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010077"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(00)80053-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2706"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536810-000000000-00000"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/01.NAJ.0000554544.80148.ee","article-title":"New warning for fluoroquinolone antibiotics","volume":"119","author":"Aschenbrenner D","year":"2019","journal-title":"Am J Nurs"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix032"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818757972"},{"key":"e_1_2_9_15_1","volume-title":"Otol Neurotol","author":"Dirain C"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816672627"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816633671"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817751093"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz345."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp078102"},{"key":"e_1_2_9_21_1","unstructured":"IBM Watson Health.White paper: IBM MarketScan Research Databases for health services researchers.https:\/\/www.ibm.com\/downloads\/cas\/6KNYVVQ2. Published2018. Accessed April 1 2019."},{"key":"e_1_2_9_22_1","unstructured":"ChandramouliJ.Ofloxacin otic solution.https:\/\/www.ashp.org\/Drug\u2010Shortages\/Current\u2010Shortages\/Drug\u2010Shortage\u2010Detail.aspx?id=90. Published2016. Accessed April 1 2019."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001955"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.05.004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215113002375"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004326.pub2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.04.039"},{"issue":"6","key":"e_1_2_9_28_1","first-page":"263","article-title":"The efficacy of ceruminolytics: everything old is new again","volume":"18","author":"Robinson AC","year":"1989","journal-title":"J Otolaryngol"},{"issue":"6","key":"e_1_2_9_29_1","first-page":"268","article-title":"The mechanism of ceruminolysis","volume":"18","author":"Robinson AC","year":"1989","journal-title":"J Otolaryngol"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1989.tb00332.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813517083"},{"issue":"11","key":"e_1_2_9_32_1","first-page":"1055","article-title":"Acute otitis externa: an update","volume":"86","author":"Schaefer P","year":"2012","journal-title":"Am Fam Physician"}],"updated-by":[{"DOI":"10.1177\/0194599820924651","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000}}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599819889607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599819889607","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599819889607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:49:09Z","timestamp":1760957349000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599819889607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,19]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/0194599819889607"],"URL":"https:\/\/doi.org\/10.1177\/0194599819889607","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,19]]},"assertion":[{"value":"2019-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}