{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:32:41Z","timestamp":1769088761020,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the potential correlation between <jats:italic>Helicobacter pylori<\/jats:italic> infection and otitis media with effusion (OME) risk in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Electronic databases were searched, including Cochrane Library, PubMed, Embase, China Biology Medicine disc, China Science and Technology Journal Database, Wanfang Database, and China National Knowledge Infrastructure Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>A systematic review and meta\u2010analysis were conducted with Revman 5.3 software. Combined odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate infection\u2010disease association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 11 studies from 9 articles regarding <jats:italic>H pylori<\/jats:italic> infection and OME risk were enrolled in this meta\u2010analysis. A significant association between <jats:italic>H pylori<\/jats:italic> infection and OME was detected for both adenoid samples from the case group (OR, 2.75; 95% CI, 1.43\u20105.30; <jats:italic>P<\/jats:italic> =. 002) and middle ear fluid samples from the case group (OR, 4.45; 95% CI, 2.52\u20107.88; <jats:italic>P<\/jats:italic> &lt;. 00001). Subgroup analyses suggested a stronger correlation in African and Asian populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicated the correlation between <jats:italic>H pylori<\/jats:italic> infection and increased risk of OME in children, especially in African and Asian populations. Further well\u2010designed studies regarding the white population are strongly recommended in the future.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820921861","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T04:03:22Z","timestamp":1591070602000},"page":"654-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association Between <i>Helicobacter pylori<\/i> Infection and Otitis Media With Effusion Risk in Children: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"163","author":[{"given":"Xiaohui","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Xiamen Children\u2019s Hospital Xiamen China"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hearing Center\/Hearing and Speech Science Laboratory West China Hospital of Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hearing Center\/Hearing and Speech Science Laboratory West China Hospital of Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingqiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Xiamen Children\u2019s Hospital Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hearing Center\/Hearing and Speech Science Laboratory West China Hospital of Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuxue","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hearing Center\/Hearing and Speech Science Laboratory West China Hospital of Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489709113440"},{"key":"e_1_2_8_3_1","first-page":"381","volume-title":"Dev Med Child Neurol","author":"American Academy of Family Physicians","year":"1997"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"511","article-title":"Otitis media with effusion","volume":"39","author":"Williamson I","year":"2002","journal-title":"Dev Med Child Neurol"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"5","article-title":"Immunologic aspects of otitis media with effusion","volume":"37","author":"Mogi G","year":"1983","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.07.061"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"261","article-title":"Helicobacter pylori may cause otitis media with effusion: a pilot study","volume":"8","author":"Bai X","year":"2012","journal-title":"B\u2010ENT"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.08.013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200405000-00020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666120-00003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.09.026"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2018.11.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000787"},{"issue":"24","key":"e_1_2_8_15_1","first-page":"4275","article-title":"Helicobacter pylori in middle ear of children with otitis media with effusion","volume":"124","author":"Park C","year":"2011","journal-title":"Chin Med J"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.15694"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.11.023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.12.009"},{"issue":"21","key":"e_1_2_8_19_1","first-page":"27","article-title":"Helicobacter pylori infection and cyclooxygenase\u20102 expression in the secretory otitis media in patients with correlation","author":"Liu Q","year":"2010","journal-title":"J Pract Med (Chinese)"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.02.002"},{"issue":"14","key":"e_1_2_8_21_1","first-page":"1315","article-title":"Gastroesophageal reflux and otitis media with effusion","volume":"29","author":"Tian X","year":"2015","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.4.296"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00767.x"},{"key":"e_1_2_8_24_1","volume-title":"Gene Expression and Gastric Reflux in Chronic Rhinosinusitis and Otitis Media with Effusion","author":"Viswanathan H","year":"2007"},{"issue":"1","key":"e_1_2_8_25_1","first-page":"38","article-title":"Is otitis media with effusion the result of a biofilm infection?","volume":"29","author":"Fergie N","year":"2004","journal-title":"Systems Analysis Modelling Simulation"},{"issue":"4","key":"e_1_2_8_26_1","first-page":"565","article-title":"Linking laryngopharyngeal reflux to otitis media with effusion: pepsinogen study of adenoid tissue and middle ear fluid","volume":"37","author":"Alsaab F","year":"2008","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215115002182"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2012.02.004"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599820921861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599820921861","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599820921861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:42:13Z","timestamp":1760956933000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599820921861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,2]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1177\/0194599820921861"],"URL":"https:\/\/doi.org\/10.1177\/0194599820921861","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,2]]},"assertion":[{"value":"2019-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}