{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:28:56Z","timestamp":1769110136427,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare growth trends among infants with Pierre Robin sequence (PRS) to normal World Health Organization (WHO) growth standards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Twenty\u2010four infants with syndromic and nonsyndromic PRS (54% male) treated at an urban academic medical center between 2009 and 2017 were included. Infants with symptomatic hypoventilation underwent mandibular distraction osteogenesis (71%). Weights were recorded at roughly 1\u2010 to 3\u2010month intervals from birth to 12\u00a0months, with ages adjusted for prematurity. The 50th percentile (P50) for this cohort was calculated and compared to WHO standards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 135 weight entries for 24 subjects were included. The birth weight P50 was similar to the WHO standard (females: 0.09\u00a0kg above WHO [95% CI, \u20130.25 to +0.43; <jats:italic>z<\/jats:italic> score = 0.19]; males: 0.38\u00a0kg below WHO [95% CI, \u20130.77 to 0.00; <jats:italic>z<\/jats:italic> score = \u22120.79]). A slower growth rate was noted among female and male infants with PRS: in month 5, the PRS P50 among females was 1.42\u00a0kg below the WHO standard (95% CI, \u20131.77 to \u22121.07; <jats:italic>z<\/jats:italic> score = \u22121.64). Among males in month 3, the PRS P50 was 1.68\u00a0kg below the WHO standard (95% CI, \u20132.12 to \u22121.24; <jats:italic>z<\/jats:italic> score = \u22122.19). By month 12, weight deficiencies had resolved in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Newborns with and without PRS may have similar birth weights, but the growth rate among male and female infants with PRS may lag behind that of unaffected infants, even when upper airway obstruction has been addressed in early infancy.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820925454","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T12:29:27Z","timestamp":1589891367000},"page":"1032-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Weight Gain in Infants With Pierre Robin Sequence in the First Year of Life"],"prefix":"10.1002","volume":"163","author":[{"given":"Leo","family":"Li","sequence":"first","affiliation":[{"name":"Tufts University School of Medicine Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Scott","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Tufts Medical Center Boston Massachusetts USA"},{"name":"Division of Pediatric Otolaryngology and Facial Plastic Surgery Floating Hospital for Children at Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24782"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1597\/02-055"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37150"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306472"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37538"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2018.11.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1320065"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310000646"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(05)80009-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb00133.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1996-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-6383(98)90039-X"},{"issue":"4","key":"e_1_2_9_15_1","first-page":"270","article-title":"Clinical experience with the Robin sequence","volume":"21","author":"Pasyayan HM","year":"1984","journal-title":"Cleft Palate J"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb18273.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00664.x"},{"issue":"2","key":"e_1_2_9_18_1","first-page":"146","article-title":"Weight gain in children with cleft palate from birth to two years","volume":"25","author":"Seth AK","year":"1988","journal-title":"Cleft Palate J"},{"key":"e_1_2_9_19_1","first-page":"400","article-title":"Height\u2010weight growth of cleft children, birth to six years","volume":"12","author":"Ranalli DN","year":"1975","journal-title":"Cleft Palate J"},{"key":"e_1_2_9_20_1","unstructured":"World Health Organization.The WHO child growth standards. PublishedJune 8 2016. Accessed October 1 2019.www.who.int\/childgrowth\/standards\/en"},{"issue":"7","key":"e_1_2_9_21_1","first-page":"829","article-title":"Failure to thrive: an update","volume":"83","author":"Cole SZ","year":"2011","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.3.241"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1652"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25440"},{"issue":"3","key":"e_1_2_9_25_1","first-page":"258","article-title":"Cleft lip and palate in Denmark, 1976\u20101981: epidemiology, variability, and early somatic development","volume":"25","author":"Jensen BL","year":"1988","journal-title":"Cleft Palate J"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004650"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992288001900802"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200411000-00009"},{"key":"e_1_2_9_29_1","first-page":"973240","article-title":"Weight gain in children with cleft lip and palate without use of palatal plates","volume":"2012","author":"Freitas R","year":"2012","journal-title":"Plast Surg Int"},{"issue":"1","key":"e_1_2_9_30_1","first-page":"24","article-title":"Impaired weight gain in cleft palate infants","volume":"17","author":"Avedian LV","year":"1980","journal-title":"Cleft Palate J"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(02)00107-6"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2016.11.009"},{"issue":"8","key":"e_1_2_9_33_1","first-page":"213","article-title":"Infant and maternal characteristics in neonatal abstinence syndrome\u2014selected hospitals in Florida. 2010\u20102011","volume":"64","author":"Lind JN","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2010.01.020"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1597\/14-003"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599820925454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599820925454","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599820925454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:13:18Z","timestamp":1760962398000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599820925454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1177\/0194599820925454"],"URL":"https:\/\/doi.org\/10.1177\/0194599820925454","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]},"assertion":[{"value":"2019-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}