{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:51:21Z","timestamp":1790664681811,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) is a global pandemic affecting millions of individuals, killing hundreds of thousands. Although typically described with characteristic symptoms of fever, cough, and shortness of breath, greater understanding of COVID\u201019 has revealed myriad clinical manifestations. Olfactory dysfunction (OD)\u2014hyposmia and anosmia\u2014has recently been recognized as an important symptom of COVID\u201019 and increasingly gained traction as a public health tool for identifying COVID\u201019 patients, in particular otherwise asymptomatic carriers who, unawares, may be major drivers of disease spread. The objective of this study is to review the scientific evidence about anosmia in COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>PubMed, Google Scholar, and Web of Science.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Comprehensive literature search of primary studies pertinent to the objectives of this review using the chosen data sources.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Current evidence shows that OD is highly prevalent in COVID\u201019, with up to 80% of patients reporting subjective OD and objective olfactory testing potentially showing even higher prevalence. OD is frequently accompanied by taste dysfunction. Up to 25% of COVID\u201019 patients may experience sudden\u2010onset OD as the first symptom. A large proportion of COVID\u201019 OD cases may resolve over the period of a few weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications for Practice<\/jats:title><jats:p>Sudden anosmia should be considered a symptom of COVID\u201019. Assessing for sudden\u2010onset anosmia may increase sensitivity of COVID\u201019 screening strategies, in particular for identifying patients at the earliest stages of disease. Since many cases of OD due to COVID\u201019\u00a0may resolve in the short term, conservative management, including observation, is reasonable, while advanced imaging is unnecessary.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820926464","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T04:00:34Z","timestamp":1588651234000},"page":"12-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Olfactory Dysfunction: A Highly Prevalent Symptom of COVID\u201019 With Public Health Significance"],"prefix":"10.1002","volume":"163","author":[{"given":"Ahmad R.","family":"Sedaghat","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Cincinnati Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Gengler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Cincinnati Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene M.","family":"Speth","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals\u2010, Nasen\u2010, Ohren\u2010 Krankheiten, Hals\u2010und Gesichtschirurgie Kantonsspital Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-020-00240-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.116"},{"key":"e_1_2_7_4_1","article-title":"Coincidence of COVID\u201019 epidemic and olfactory dysfunction outbreak","author":"Bagheri SHR","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.384"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28692"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa330"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05965-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22579"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22587"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2020.04.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.0832"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.114"},{"key":"e_1_2_7_14_1","volume-title":"Otolaryngol Head Neck Surg","author":"Kaye R"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599820926464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599820926464","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599820926464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:16:13Z","timestamp":1760955373000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599820926464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,5]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1177\/0194599820926464"],"URL":"https:\/\/doi.org\/10.1177\/0194599820926464","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,5]]},"assertion":[{"value":"2020-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}