{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:16:30Z","timestamp":1770596190207,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Peritonsillar abscesses (PTAs) are common emergency consultations for otolaryngologists. Medical management alone may offer satisfactory treatment without the risk associated with surgical drainage. Therefore, we performed a systematic review of medical treatment alone compared to surgical drainage for the treatment of PTA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>MEDLINE, EMBASE, Cochrane CENTRAL, and ClinicalTrials.gov.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Studies comparing the outcomes of medically treated to surgically treated patients were included. Risk of bias was assessed using the Newcastle\u2010Ottawa Scale. All screening and data extraction were completed by 2\u00a0independent reviewers. Meta\u2010analysis was performed using a random\u2010effects model. Subgroup and sensitivity analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten cohort studies and 2 randomized studies were included (n<jats:sub>total<\/jats:sub> = 33,468). Study quality was low, with only 1 study providing multivariable analysis. The combined rate of treatment failure in patients initially treated with medical management alone was 5.7% compared to 5.5% in the surgical group. There was no statistically significant difference in the odds of treatment failure between interventions through random\u2010effects meta\u2010analysis (odds ratio [OR], 1.10; 95% CI, 0.53\u20102.26; <jats:italic>I<\/jats:italic>\n<jats:sup>2<\/jats:sup> = 41%; <jats:italic>P<\/jats:italic> =. 13). Subgroup analysis excluding pediatric\u2010specific studies revealed similar odds of treatment failure when initially managed with medical intervention (OR, 0.92; 95% CI, 0.56\u20101.50; <jats:italic>P<\/jats:italic> =. 39; <jats:italic>I<\/jats:italic>\n<jats:sup>2<\/jats:sup> = 0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Meta\u2010analysis of available studies demonstrated no difference in odds of treatment failure for patients with PTA managed through medical intervention alone compared to surgical intervention. These findings should be interpreted with caution due to high probability of bias and overall low quality of studies.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820927328","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T04:01:54Z","timestamp":1591070514000},"page":"915-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Medical Intervention Alone vs Surgical Drainage for Treatment of Peritonsillar Abscess: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"163","author":[{"given":"David","family":"Forner","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head &amp; Neck Surgery Dalhousie University Halifax Nova Scotia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis E.","family":"Curry","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head &amp; Neck Surgery Dalhousie University Halifax Nova Scotia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy","family":"Hancock","sequence":"additional","affiliation":[{"name":"W. 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