{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:07:48Z","timestamp":1776960468619,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify risk factors associated with intubation and time to extubation in hospitalized patients with coronavirus disease 2019 (COVID\u201019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Ten hospitals in the Chicago metropolitan area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Patients with laboratory\u2010confirmed COVID\u201019 admitted between March 1 and April 8, 2020, were included. We evaluated sociodemographic and clinical characteristics associated with intubation and prolonged intubation for acute respiratory failure secondary to COVID\u201019\u00a0infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 486 hospitalized patients included in the study, the median age was 59 years (interquartile range, 47\u201069); 271 (55.8%) were male; and the median body mass index was 30.6 (interquartile range, 26.5\u201035.6). During the hospitalization, 138 (28.4%) patients were intubated; 78 (56.5%) were eventually extubated; 21 (15.2%) died; and 39 (28.3%) remained intubated at a mean \u00b1 SD follow\u2010up of 19.6 \u00b1 6.7\u00a0days. Intubated patients had a significantly higher median age (65 vs 57 years, <jats:italic>P<\/jats:italic> &lt;. 001) and rate of diabetes (56 [40.6%] vs 104 [29.9%], <jats:italic>P<\/jats:italic> =. 031) as compared with nonintubated patients. Multivariable logistic regression analysis identified age, sex, respiratory rate, oxygen saturation, history of diabetes, and shortness of breath as factors predictive of intubation. Age and body mass index were the only factors independently associated with time to extubation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In addition to clinical signs of respiratory distress, patients with COVID\u201019 who are older, male, or diabetic are at higher risk of requiring intubation. Among intubated patients, older and more obese patients are at higher risk for prolonged intubation. Otolaryngologists consulted for airway management should consider these factors in their decision making.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820929640","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T04:01:58Z","timestamp":1589860918000},"page":"170-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["Factors Associated With Intubation and Prolonged Intubation in Hospitalized Patients With COVID\u201019"],"prefix":"10.1002","volume":"163","author":[{"given":"Kevin","family":"Hur","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline P. E.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth L.","family":"Gray","sequence":"additional","affiliation":[{"name":"Biostatistics Collaboration Center Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reeti K.","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Maksimoski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University Chicago Illinois 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