{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:23Z","timestamp":1787018723018,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Guideline recommendations for the treatment of early\u2010stage glottic cancer are limited to single\u2010modality therapy with surgery or radiation alone. We sought to investigate the clinicopathologic and treatment factors associated with the use of postoperative radiation therapy (PORT) following laser excision for patients with T1\u2010T2N0 glottic squamous cell carcinoma (SCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective observational study of the National Cancer Database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>National Cancer Database review from 2004 to 2014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A total of 1338 patients with primary cT1\u2010T2N0M0 glottic SCC undergoing primary laser excision were included. Hospitals were divided into quartiles based on yearly volume of laryngeal laser cases performed. Multivariate logistic regression was performed to identify independent predictors of PORT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall rate of PORT was 30.0%. Predictors of PORT included treatment at lower\u2010volume hospitals (adjusted odds ratio [aOR] for quartiles 2\u20104, 1.32\u20104.84), positive margins (aOR, 3.83 [95% CI, 2.54\u20105.78]), and T2 tumors (aOR, 3.58 [95% CI, 2.24\u20105.74]). PORT utilization demonstrated a strong inverse correlation with hospital volume. Among top\u2010quartile hospitals, the rate of PORT was 11.2%, while rates of PORT at second\u2010, third\u2010, and fourth\u2010quartile institutions were 19.2%, 32.2%, and 37.4%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Predictors of PORT in multivariable analysis included treatment at lower\u2010volume facilities, positive margins, and T2 disease. This study highlights the importance of treating early\u2010stage glottic carcinoma at high\u2010volume institutions. In addition, there is a need to reevaluate the use of PORT and reduce the rate of dual\u2010modality therapy for patients with early\u2010stage glottic SCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599820933183","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T04:14:10Z","timestamp":1594095250000},"page":"1218-1225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictors of Postoperative Radiation Following Laser Resection in Early\u2010Stage Glottic Cancer"],"prefix":"10.1002","volume":"163","author":[{"given":"Dustin A.","family":"Silverman","sequence":"first","affiliation":[{"name":"Division of Head and Neck Oncology Department of Otolaryngology\u2013Head and Neck Surgery The Ohio State University James Cancer Center and Solove Research Institute Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Y.","family":"Zhan","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Oncology Department of Otolaryngology\u2013Head and Neck Surgery The Ohio State University James Cancer Center and Solove Research Institute Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidharth V.","family":"Puram","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine Siteman Cancer Center Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Eskander","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Sunnybrook Health Sciences Centre University of Toronto Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto Ontario 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