{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:50:46Z","timestamp":1777949446897,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The coronavirus disease 2019 (COVID\u201019) pandemic poses a threat to global health. Early diagnosis is an essential key to limit the outbreak of the virus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series, study conducted between March 25, 2020, and April 15, 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Ambulatory, nonhospitalized patients who were quarantined in a designated hotel for COVID\u201019 patients and were recruited by an advertisement at the hotel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>In total, 140 patients participated in a web\u2010based questionnaire assessing initial symptoms of common viral diseases, olfactory and taste functions, xerostomia, and orofacial pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 58\u00a0men and 70 women participated. Initial symptoms were cough (59.4%), weakness (47.7%), myalgia (46.9%), fever (42.2%), headache (40.6%), impaired sense of smell (38.3%), impaired sense of taste (32.8%), sore throat (26.6%), runny nose (26.6%), and nasal congestion (22.7%). All symptoms were more frequent among women; however, only runny nose was statistically significant (<jats:italic>P<\/jats:italic> =. 018). The most common combination of symptoms was cough and weakness (37.5%). A total of 25.8% reported olfactory and taste dysfunctions in the absence of other symptoms. In a comparison between the sexes, cough and runny nose were the most common combination in women (<jats:italic>P<\/jats:italic> =. 018). A total of 38.3% of patients reported olfactory dysfunction as an initial symptom. Anosmia and facial pain were more common among women (<jats:italic>P<\/jats:italic> &lt;. 001 and <jats:italic>P<\/jats:italic> =. 01, respectively), and 56% of patients reported xerostomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A considerable number of patients presented with olfactory and oral disorders. Interestingly, women presented with a different cluster of symptoms than men, which may suggest a new clinical approach to diagnosing COVID\u201019 disease.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820934380","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T04:01:37Z","timestamp":1592280097000},"page":"722-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":146,"title":["Olfactory and Oral Manifestations of COVID\u201019: Sex\u2010Related Symptoms\u2014A Potential Pathway to Early Diagnosis"],"prefix":"10.1002","volume":"163","author":[{"given":"Ameen","family":"Biadsee","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Meir Medical Center Kfar Saba Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameer","family":"Biadsee","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas","family":"Kassem","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Meir Medical Center Kfar Saba Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Or","family":"Dagan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Hillel Yaffe Medical Center Hadera Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shchada","family":"Masarwa","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeev","family":"Ormianer","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.03.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30313-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-020-01591-x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-020-0767-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102433"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.02.034"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30061-X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22809"},{"key":"e_1_2_10_11_1","unstructured":"There\u2019s an unexpected loss of smell and taste in coronavirus patients. 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