{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:43:58Z","timestamp":1761007438620,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC12015114"],"award-info":[{"award-number":["SHDC12015114"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to evaluate the potential predictor of tumor size on rates of overall and disease\u2010free survival (OS and DFS) as determined by postoperative pathologic examination in patients with glottic carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>In this study, 1337 consecutive patients with glottic carcinoma who underwent surgical treatment from 2005 to 2010 were retrospectively reviewed. The influence of tumor size that was evaluated by tumor area (tumor length \u00d7 tumor width) on OS and DFS outcomes was assessed by Cox regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 1303 (97.5%) patients were male, and 34 (2.5%) were female, with a mean \u00b1 SD age of 60.4 \u00b1 10 years. The 10\u2010year OS and DFS rates were 72.9% and 69.9%, respectively. The tumor area cutoff values that best discriminated OS and DFS rates were both 1.80\u00a0cm<jats:sup>2<\/jats:sup>. Patients with glottic carcinoma with a larger tumor area had inferior OS and DFS rates. Based on the results of multivariate analyses, tumor area was an independent prognostic factor for rates of OS (hazard ratio, 1.87; 95% CI, 1.37\u20102.56; <jats:italic>P<\/jats:italic> &lt;. 001) and DFS (hazard ratio, 1.79; 95% CI, 1.34\u20102.38; <jats:italic>P<\/jats:italic> &lt;. 001) in patients with glottic carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study indicate that patients with glottic carcinoma with a tumor area &gt;1.8\u00a0cm<jats:sup>2<\/jats:sup> have inferior survival outcomes, and this factor independently predicts survival outcomes in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820937296","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T12:02:02Z","timestamp":1594123322000},"page":"353-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pathologic Tumor Size as a Predictor of the Survival Outcomes of Patients With Glottic Carcinoma"],"prefix":"10.1002","volume":"164","author":[{"given":"Hongli","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University Shanghai 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