{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:21Z","timestamp":1787018721775,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated the effects of bumetanide alone and in combination with dexamethasone on facial nerve regeneration in rats with facial paralysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A prospective controlled animal study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>An animal laboratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Facial paralysis was induced in 32 Wistar rats that we then divided into 4\u00a0groups: group 1, control; group 2, bumetanide; group 3, dexamethasone; group 4, bumetanide and dexamethasone. Electroneurography was performed 1, 2, and 4 weeks later, and nerve regeneration was evaluated by electron and light microscopy and Western blotting in week 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Regarding the comparison between preoperative values and week 4, the latency difference in group 1 (1.25\u00a0milliseconds) was significantly higher than those of groups 2 to 4 (0.56, 0.34, and 0.10\u00a0milliseconds, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      =. 001). The latency increment in groups 2 and 3 was higher than that of group 4 (\n                      <jats:italic>P<\/jats:italic>\n                      =. 002 and\n                      <jats:italic>P<\/jats:italic>\n                      =. 046) in week 4, whereas groups 2 and 3 did not differ significantly (\n                      <jats:italic>P<\/jats:italic>\n                      =. 291). Amplitude difference was not statistically significant from week 4 among all groups (all\n                      <jats:italic>P &gt;<\/jats:italic>\n                      . 05). The number of myelinated axons was significantly higher in all treatment groups than in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      =. 001). Axon number and intensity were significantly higher in group 4 as compared with groups 2 and 3 (\n                      <jats:italic>P<\/jats:italic>\n                      =. 009,\n                      <jats:italic>P<\/jats:italic>\n                      =. 005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After primary neurorrhaphy, dexamethasone and bumetanide alone promoted nerve recovery based on electrophysiologic and histologic measures. Combination therapy was, however, superior.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599820937670","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T04:21:15Z","timestamp":1593490875000},"page":"117-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Bumetanide on Facial Nerve Regeneration in Rat Model"],"prefix":"10.1002","volume":"164","author":[{"given":"Ecem Sevim","family":"Longur","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Ercis State Hospital Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Yi\u011fit","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Health Sciences Istanbul Training and Research Hospital Istanbul 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