{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:30:29Z","timestamp":1761006629097,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Airway epithelia express intrinsic antimicrobial and nutrient\u2010sequestering factors, which contribute to the host defense of the respiratory tract. Hepcidin is an endogenous peptide hormone that serves as a key regulator of iron metabolism, and ferroportin and ZIP8 are iron transporters. All exhibit innate antimicrobial activity. The purpose of this pilot study is to determine if molecules involved in iron regulation are expressed within sinus epithelia and to compare levels of expression between patients with and without chronic rhinosinusitis (CRS). Sinus mucosa was obtained from patients with (n = 19) and without (n = 14) CRS. Real\u2010time polymerase chain reaction following RNA extraction was used to quantify expression of hepcidin, ferroportin, and ZIP8\u00a0mRNA. Hepcidin, ferroportin, and ZIP8 were all detected in the sinus epithelia of patients with and without CRS. However, only ZIP8 was significantly changed in CRS, with a 2.5\u2010fold mean increase in mRNA expression relative to controls (<jats:italic>P<\/jats:italic> =. 005). These findings suggest that ZIP8\u00a0may play a role in the innate epithelial defense of the paranasal sinuses.<\/jats:p>","DOI":"10.1177\/0194599820939910","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T04:11:41Z","timestamp":1596514301000},"page":"1270-1273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Expression of Iron\u2010Regulatory Hormone Hepcidin and Iron Transporters Ferroportin and ZIP8\u00a0in Patients With and Without Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"163","author":[{"given":"David","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery University of California Los Angeles David Geffen School of Medicine Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Airie","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine 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