{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:29:42Z","timestamp":1790360982736,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>While olfactory dysfunction associated with coronavirus disease 2019 (COVID\u201019) has attracted considerable interest, few studies have tracked outcomes at serial time points or beyond 2 weeks. Furthermore, data are conflicting regarding whether COVID\u201019 severity correlates with degree of olfactory dysfunction. This prospective case\u2010control study analyzed prevalence and severity of subjective loss of smell in outpatients (n = 23) and inpatients (n = 20) with confirmed severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection vs healthy controls (n = 25). Olfactory dysfunction was reported more commonly in COVID\u201019 patients than in healthy controls (<jats:italic>P<\/jats:italic> &lt;. 001), and outpatients paradoxically reported loss of smell more commonly than inpatients (<jats:italic>P<\/jats:italic> =. 02). Headaches were present in 52% of patients with olfactory dysfunction. Anosmia or hyposmia persisted beyond 5\u00a0days but most of the patients recovered by 30\u00a0days, suggesting favorable prognosis for olfaction. Differences between inpatients and outpatients are potentially reflective of timeline of olfactory symptoms and contextual factors, underscoring the importance of corroborative objective testing, coupled with careful tracking of temporal relationships.<\/jats:p>","DOI":"10.1177\/0194599820943530","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T11:34:38Z","timestamp":1594726478000},"page":"82-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Olfactory Dysfunction in COVID\u201019\u00a0Patients: Prevalence and Prognosis for Recovering Sense of Smell"],"prefix":"10.1002","volume":"164","author":[{"given":"Luca","family":"D\u2019Ascanio","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery Institute of Otorhinolaryngology Santa Croce Hospital AORMN Fano\u2010Pesaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlio","family":"Pandolfini","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Institute of Otorhinolaryngology Santa Croce Hospital AORMN Fano\u2010Pesaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cingolani","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Institute of Otorhinolaryngology Santa Croce Hospital AORMN Fano\u2010Pesaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Latini","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Institute of Otorhinolaryngology Santa Croce Hospital AORMN Fano\u2010Pesaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gradoni","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Institute of Otorhinolaryngology Santa Croce Hospital AORMN Fano\u2010Pesaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Capalbo","sequence":"additional","affiliation":[{"name":"AORMN Pesaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Frausini","sequence":"additional","affiliation":[{"name":"Internal Medicine Department \u201cSanta Croce Hospital\u201d AORMN Fano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Maranzano","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial and Facial Plastic Surgery Manchester University Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of Michigan Medical School Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Di Stadio","sequence":"additional","affiliation":[{"name":"Arianna Di Stadio Department of Otolaryngology\u2013Head &amp; Neck Surgery University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-020-1661-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25757"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.10.2000180"},{"issue":"7","key":"e_1_2_8_5_1","first-page":"3440","article-title":"Defining the burden of olfactory dysfunction in COVID\u201019 patients","volume":"24","author":"Ralli M","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06069-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820929185"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820929957"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26269"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25721"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6771"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26204"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820932128"},{"key":"e_1_2_8_14_1","unstructured":"World Health Organization.Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance. 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