{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:19:05Z","timestamp":1783937945298,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to evaluate benefits in terms of time and cost of percutaneous ultrasound\u2010guided fine\u2010needle aspiration biopsy\/core\u2010needle biopsy (US\u2010FNAB\/CNB) for the diagnosis of primary laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) in comparison with direct laryngoscopic biopsy (DLB) under general anesthesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single operator of a single center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>From 2018 to 2019, 28 patients who underwent percutaneous US\u2010FNAB\/CNB for the diagnosis of untreated LHSCC were enrolled. All US\u2010FNAB\/CNBs were performed in the outpatient department by a single head and neck surgeon. Their results were compared with those of 27 patients who underwent DLB under general anesthesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No major complications occurred in the US\u2010FNAB\/CNB and DLB groups. Time to biopsy, time to pathologic diagnosis, and time to treatment initiation in the US\u2010FNAB\/CNB and DLB groups were 0 and 14\u00a0days (<jats:italic>P<\/jats:italic> &lt;. 001), 7 and 20\u00a0days (<jats:italic>P<\/jats:italic> &lt;. 001), and 24 and 35\u00a0days (<jats:italic>P<\/jats:italic> =. 001), respectively. Procedure\u2010related costs were $368.5 and $981.0\u00a0in the US\u2010FNAB\/CNB and DLB groups (<jats:italic>P<\/jats:italic> &lt;. 001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>US\u2010FNAB\/CNB offers true benefits in terms of time and cost over those given by conventional DLB for diagnosis of LHSCC in indicated patients.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820945953","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T04:10:39Z","timestamp":1595304639000},"page":"602-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Time and Cost of Ultrasound\u2010Guided Fine\u2010Needle Aspiration Biopsy\/Core\u2010Needle Biopsy for Primary Laryngohypopharyngeal Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"164","author":[{"given":"Dongbin","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery School of Medicine Kyungpook National University Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil Joon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery School of Medicine Kyungpook National University Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Ho","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery School of Medicine Kyungpook National University Daegu 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