{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:15:00Z","timestamp":1790504100867,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze auditory brainstem response (ABR) findings of preterm and term infants in the neonatal intensive care unit (NICU) with perinatal problems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Secondary care hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analysis consisted of a consecutive series of 101\u00a0infants (69 preterm and 32 term) admitted in the NICU of Hospital Fernando Fonseca between 2016 and 2018 with perinatal problems who underwent an ABR evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The major perinatal problems identified were hyperbilirubinemia, intravenous gentamicin &gt;5\u00a0days, mechanical ventilation &gt;5\u00a0days, congenital cytomegalovirus infection, meningitis, and periventricular hemorrhage. Gentamicin use significantly increased the absolute latency of wave I in preterm infants (95% CI, 0.01\u20100.37; <jats:italic>P<\/jats:italic> =. 037). Mechanical ventilation significantly decreased the latency of wave V and intervals I\u2010V and III\u2010V in preterm infants (95% CI, \u22120.35 to \u22120.22; <jats:italic>P<\/jats:italic> =. 026; 95% CI, \u22120.33 to \u22120.00; <jats:italic>P<\/jats:italic> =. 001; 95% CI, \u22120.46 to 0.12; <jats:italic>P<\/jats:italic> =. 049). Congenital cytomegalovirus significantly decreased interval III\u2010V in preterm infants (95% CI, \u22120.36 to \u22120.01; <jats:italic>P<\/jats:italic> =. 042).<\/jats:p><jats:p>Multivariate analysis revealed that gentamicin use, lower gestational age, and lower birth weight predicted an increased ABR threshold in preterm infants (95% CI, 1.64\u201015.31; <jats:italic>P<\/jats:italic> =. 016; 95% CI \u22121.72 to \u22120.09; <jats:italic>P<\/jats:italic> =. 030; 95% CI, \u221214.55 to \u22120.63; <jats:italic>P<\/jats:italic> =. 033). ABR measurements in term infants were not significantly altered, with the exception of an increased latency of wave III with a lower gestational age (95% CI, \u22120.49 to \u22120.01; <jats:italic>P<\/jats:italic> =. 038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that perinatal problems in the NICU significantly impair the ABR threshold and the auditory pathway maturational process in preterm but not term infants.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820955181","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T04:02:35Z","timestamp":1600142555000},"page":"884-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Auditory Brainstem Response in Preterm Infants in the Neonatal Intensive Care 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Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Prof Doutor Fernando Fonseca Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"Freire","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Prof Doutor Fernando Fonseca Lisbon 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