{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:05:40Z","timestamp":1792695940110,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the differences in olfactory cleft (OC) morphology in coronavirus disease 2019 (COVID\u201019) anosmia compared to control subjects and postviral anosmia related to infection other than severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>This study comprises 91 cases, including 24 cases with anosmia due to SARS\u2010CoV\u20102, 38 patients with olfactory dysfunction (OD) due to viral infection other than SARS\u2010CoV\u20102, and a control group of 29\u00a0normosmic cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All cases had paranasal sinus computed tomography (CT), and cases with OD had magnetic resonance imaging (MRI) dedicated to the olfactory nerve. The OC width and volumes were measured on CT, and T2\u2010weighted signal intensity (SI), olfactory bulb volumes, and olfactory sulcus depths were assessed on MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study showed 3\u00a0major findings: the right and left OC widths were significantly wider in anosmic patients due to SARS\u2010CoV\u20102 (group 1) or OD due to non\u2013SARS\u2010CoV\u20102 viral infection (group 2) when compared to healthy controls. OC volumes were significantly higher in group 1 or 2 than in healthy controls, and T2 SI of OC area was higher in groups 1 and 2 than in healthy controls. There was no significant difference in olfactory bulb volumes and olfactory sulcus depths on MRI among groups 1 and 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, patients with COVID\u201019 anosmia had higher OC widths and volumes compared to control subjects. In addition, there was higher T2 SI of the olfactory bulb in COVID\u201019 anosmia compared to control subjects, suggesting underlying inflammatory changes. There was a significant negative correlation between these morphological findings and threshold discrimination identification scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level 4.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820965920","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T04:01:01Z","timestamp":1602561661000},"page":"1337-1344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Olfactory Cleft Measurements and COVID\u201019\u2013Related Anosmia"],"prefix":"10.1002","volume":"164","author":[{"given":"Aytug","family":"Altundag","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Medical Faculty Biruni University Istanbul Turkey"},{"name":"Department of Ear, Nose, and Throat Acibadem Taksim Hospital Istanbul 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