{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:01:19Z","timestamp":1778043679950,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102018\u2010R1D1A1A02085328"],"award-info":[{"award-number":["NRF\u20102018\u2010R1D1A1A02085328"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102020\u2010R1A2C4002594"],"award-info":[{"award-number":["NRF\u20102020\u2010R1A2C4002594"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The effect of statin on sudden sensorineural hearing loss (SSNHL) remains unclear. Thus, this study aimed to investigate the association between prior statin use and SSNHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A nested case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Participants aged \u226540 years were enrolled from the 2002\u20102015\u00a0Korean National Health Insurance Service\u2013Health Screening Cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 5876 patients with SSNHL were matched with 23,504 control participants for age, sex, income, and region of residence. History of statin use for 2 years before SSNHL onset was investigated between the groups. The odds ratios (ORs) of the length of statin use for SSNHL stratified by age, sex, income, and region of residence were analyzed with conditional logistic regression. Dyslipidemia, total cholesterol, blood pressure, blood glucose, hemoglobin, obesity, smoking, alcohol consumption, and Charlson Comorbidity Index score were adjusted. The adjusted variables were subjected to subgroup analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SSNHL group had a longer duration of statin use than the control group (mean [SD], 81.9 [197.7] days vs 72.7 [188.0] days; <jats:italic>P<\/jats:italic> =. 001). However, statin use was not associated with SSNHL after adjusting for the confounders (adjusted OR, 1.04; 95% CI, 0.98\u20101.11; <jats:italic>P<\/jats:italic> =. 245). There was a positive correlation between statin use and SSNHL in the crude model (crude OR, 1.10; 95% CI, 1.04\u20101.16; <jats:italic>P<\/jats:italic> =. 001). However, there was no association between statin use and SSNHL in all subgroup analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Previous statin use was not associated with SSNHL.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820969630","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T16:32:54Z","timestamp":1606235574000},"page":"149-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association Between Sudden Sensorineural Hearing Loss and History of Statin Use: A Nested Case\u2010Control Study"],"prefix":"10.1002","volume":"165","author":[{"given":"So Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery CHA Bundang Medical Center CHA University Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee Hye","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery College of Medicine Hallym University Anyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanyang","family":"Min","sequence":"additional","affiliation":[{"name":"Hallym Data Science Laboratory College of Medicine Hallym University Anyang Korea"},{"name":"Graduate School of Public Health Seoul National University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Myoung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Hallym Data Science Laboratory College of Medicine Hallym University Anyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Geun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery College of Medicine Hallym University Anyang Korea"},{"name":"Hallym Data Science Laboratory 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