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To support optimal methods for assessment, we studied which factors could influence this relationship, including the concurrent impact of multiple discrete CT scoring mechanisms, colocalized imaging findings, and nasal comorbid conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Observational outcomes study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with sinonasal complaints who completed the 22\u2010item Sinonasal Outcome Test (SNOT\u201022) and underwent CT were included. Multivariate ordinal regression was utilized to assess associations. CT data were quantified with the Lund\u2010Mackay system, Zinreich system, and a direct measure of maximal mucosal thickness. The impact of incidental findings (mucous retention cysts, periapical dental disease) and nasal comorbid conditions was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 233 patients were included. SNOT\u201022\u00a0nasal scores were significantly associated with CT results when those with incidental findings were excluded, regardless of the radiologic scoring mechanism utilized: Lund\u2010Mackay regression coefficient, 0.321 (<jats:italic>P<\/jats:italic> =. 046); Zinreich, 0.340 (<jats:italic>P<\/jats:italic> =. 033); and maximum mucosal thickness, 0.316 (<jats:italic>P<\/jats:italic> =. 040). This relationship subsided when incidental findings were present. SNOT\u201022 overall scores, sleep scores, and psychological domain scores had no significant association with imaging results, regardless of radiologic scoring system utilized. Nasal comorbid conditions had inconsistent associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SNOT\u201022\u00a0nasal domain scores were associated with all 3\u00a0radiologic scoring systems when incidental findings were absent but not when they were present. Delineating the presence or absence of these colocalized findings affected the relationship between SNOT\u201022 scores and radiological results, beyond other concurrent factors.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820972672","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T14:41:47Z","timestamp":1605019307000},"page":"215-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sinonasal Outcome Scores and Imaging: A Concurrent Assessment of Factors Influencing Their Association"],"prefix":"10.1002","volume":"165","author":[{"given":"Allen S.","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A.","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Z.","family":"Maxfield","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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