{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:23Z","timestamp":1787018723171,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the survival implications of human papillomavirus (HPV) positivity and subtype in larynx cancer through a national cancer database. To investigate staging discrepancies in larynx cancer associated with HPV status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>National Cancer Database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted concerning adults with known HPV status who were treated between 2010 and 2016 for laryngeal squamous cell carcinoma. Patients without known HPV subtype were excluded. Cox multivariable regression models were fit to evaluate the survival impact of HPV status, characterized as a binary variable (HPV+ vs HPV\u2013) and by subtype. Two\u2010 and 5\u2010year survival rates were calculated via the Kaplan\u2010Meier method and compared by stage between the HPV+ and HPV\u2013 cohorts per the log\u2010rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with HPV+ larynx cancer were younger (60.5 vs 64.3 years,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;. 001), more likely to have private insurance (37.2% vs 31.2%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;. 001), more commonly White (84.6% vs 82.4%,\n                      <jats:italic>P<\/jats:italic>\n                      =. 013), and more likely to present with nodal disease (42.6% vs 33.0%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;. 001). HPV positivity and HPV subtype 16 were associated with improved overall survival. One\u2010stage discrepancies in 5\u2010year survival were observed between the HPV+ and HPV\u2013 cohorts: stage II HPV+ (69.45%) vs stage I HPV\u2013 (65.77%); stage IV HPV+ (47.67%) vs stage III HPV\u2013 (46.80%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HPV positivity and infection with HPV subtype 16 are correlated with improved overall survival in patients with laryngeal squamous cell carcinoma, manifesting with a 1\u2010stage incremental survival advantage. Future prospective studies are indicated to corroborate the findings from this large\u2010population database retrospective study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599820976178","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T04:24:46Z","timestamp":1606796686000},"page":"113-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic Significance of HPV Status in Laryngeal Squamous Cell Carcinoma: A Large\u2010Population Database Study"],"prefix":"10.1002","volume":"165","author":[{"given":"Bharat A.","family":"Panuganti","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery University of California\u2013San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Finegersh","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery University of California\u2013San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Flagg","sequence":"additional","affiliation":[{"name":"School of Medicine University of California\u2013San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tu","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics Department of Family Medicine and Public Health University of California\u2013San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Orosco","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery University of California\u2013San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Weissbrod","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery University of California\u2013San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Califano","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery University of California\u2013San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Transoral surgery followed by low\u2010dose or standard\u2010dose radiation therapy with or without chemotherapy in treating patients with HPV positive stage III\u2010IVA oropharyngeal cancer. Accessed June 25 2020.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01898494"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/137653"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.0395"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)70471\u20101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv086"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_199697"},{"issue":"5","key":"e_1_2_8_8_1","first-page":"299","article-title":"HPV in oropharyngeal cancer: the basics to know in clinical practice","volume":"34","author":"Elrefaey S","year":"2014","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41199\u2010018\u20100031\u2010y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy103"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy072"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis698"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30353"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25314"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010002\u20100692\u2010y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28811"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959\u20108049(95)00628\u20101"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115914"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(15)00560\u20104"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599820976178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599820976178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599820976178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:19:58Z","timestamp":1760962798000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599820976178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1177\/0194599820976178"],"URL":"https:\/\/doi.org\/10.1177\/0194599820976178","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"2020-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}