{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:18:50Z","timestamp":1791562730688,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate long\u2010term disease\u2010specific survival (DSS) and organ preservation (OP) rates in patients affected by Tis\u2010T2 glottic squamous cell carcinoma (SCC) treated by carbon dioxide transoral laser microsurgery (CO<jats:sub>2<\/jats:sub> TOLMS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Single\u2010center retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary academic hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included patients treated by CO<jats:sub>2<\/jats:sub> TOLMS for Tis\u2010T2 glottic SCC at the Department of Otorhinolaryngology\u2013Head and Neck Surgery of the University of Brescia, Italy, from 1988 to 2018. The male:female ratio was 11.2:1, and the mean age was 64 years (range, 31\u201095). T categories were distributed as follows: 124 (10%) Tis, 646 (54%) T1a, 172 (15%) T1b, and 246 (21%) T2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten\u2010 and 20\u2010year DSS rates were 97.6% and 96.3%, respectively, and 10\u2010 and 20\u2010year OP rates were 94.7% and 93%. During the follow\u2010up, 91% of patients were treated by CO<jats:sub>2<\/jats:sub> TOLMS alone, while the remaining needed adjunctive treatments. Assessing the impact of multiple sessions of CO<jats:sub>2<\/jats:sub> TOLMS, DSS showed no significant difference in terms of patients treated by 1, 2, or &gt;2 procedures. Conversely, patients treated by &gt;2 sessions of CO<jats:sub>2<\/jats:sub> TOLMS showed a significantly worse OP rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our series validates CO<jats:sub>2<\/jats:sub> TOLMS as a long\u2010term treatment strategy for early glottic SCC. Salvage CO<jats:sub>2<\/jats:sub> TOLMS provided optimal results in terms of DSS and OP in patients with recurrence after previous transoral surgery.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599820983727","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T17:56:20Z","timestamp":1610560580000},"page":"321-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Long\u2010term Oncologic Outcomes of 1188 Tis\u2010T2 Glottic Cancers Treated by Transoral Laser Microsurgery"],"prefix":"10.1002","volume":"165","author":[{"given":"Cesare","family":"Piazza","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Brescia ASST\u2013Spedali Civili of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Paderno","sequence":"additional","affiliation":[{"name":"Department of 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