{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:26:17Z","timestamp":1771550777703,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002871","name":"Chubu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>A single\u2010nucleotide polymorphism 538G&gt;A in the human <jats:italic>ABCC11<\/jats:italic> gene is a determinant of the earwax morphotype. <jats:italic>ABCC11<\/jats:italic> 538GG and GA correspond to wet earwax and 538AA to dry earwax. Despite a putative positive correlation between the frequency of the 538G allele and the prevalence of cholesteatoma, minimal clinical information is currently available. We aimed to evaluate this association between the <jats:italic>ABCC11<\/jats:italic> genotypes and acquired middle ear cholesteatoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single\u2010center academic hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 67\u00a0Japanese patients with acquired middle ear cholesteatoma (cholesteatoma group) and 100\u00a0Japanese controls with no history of middle ear cholesteatoma. We assessed the <jats:italic>ABCC11<\/jats:italic> genotypes for all participants. Clinical information was collected from the cholesteatoma group. The genotype data of 104\u00a0Japanese people from the 1000 Genomes Project who represent the general population were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of participants with <jats:italic>ABCC11<\/jats:italic> 538GG or GA was significantly higher in the cholesteatoma group than in the control group or general Japanese population (<jats:italic>P<\/jats:italic> &lt;. 001). The <jats:italic>ABCC11<\/jats:italic> 538G allele frequency was also significantly higher in the cholesteatoma group than in the control group or general Japanese population (<jats:italic>P<\/jats:italic> &lt;. 001). Multivariate logistic regression analyses revealed a significant association between the <jats:italic>ABCC11<\/jats:italic> genotype and acquired middle ear cholesteatoma (odds ratio, 5.49; 95% CI, 2.61\u201011.5; <jats:italic>P<\/jats:italic> &lt;. 001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the <jats:italic>ABCC11<\/jats:italic> genotypes could be associated with the development of acquired middle ear cholesteatoma among Japanese people.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998211000374","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T19:55:52Z","timestamp":1615924552000},"page":"139-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association Between Earwax\u2010Determinant Genotypes and Acquired Middle Ear Cholesteatoma in a Japanese Population"],"prefix":"10.1002","volume":"166","author":[{"given":"Satoshi","family":"Hara","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Graduate School of Medicine Juntendo University Tokyo Japan"},{"name":"Department of Otorhinolaryngology Faculty of Medicine Juntendo University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine Juntendo University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry Graduate School of Bioscience and Biotechnology Chubu University Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The University of Tokyo Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuko","family":"Nojiri","sequence":"additional","affiliation":[{"name":"Medical Technology Innovation Center Juntendo University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazusaku","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine Juntendo University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine Juntendo University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine Juntendo University Tokyo 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