{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:33:29Z","timestamp":1792020809490,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>M\u00e9ni\u00e8re\u2019s disease (MD) is a well\u2010known inner ear disease; however, the etiopathogenesis is unknown. Several factors may be involved. Meanwhile, vitamin D is reported to have an important role in inner ear physiology. The aim of this study is to evaluate the relation between vitamin D deficiency and MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This matched case\u2010control study compared serum vitamin D levels between patients with definite MD and those without it.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The study was done between August 2018 and December 2019 at Ghaem University Hospital in Mashhad, Iran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010eight patients with definite MD were matched with a group of 84 healthy individuals, regarding age, sex, body mass index, and occupation (indoor vs outdoor). The serum level of vitamin D (25\u2010hydroxyvitamin D3) was measured in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean \u00b1 SD vitamin D level was 18.9 \u00b1 9.7\u00a0ng\/mL in the case group and 25.2 \u00b1 13.7\u00a0ng\/mL in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      =. 027). There was a significant difference between the case and control groups according to the results of the conditional logistic regression model (\n                      <jats:italic>P<\/jats:italic>\n                      =. 03; adjusted odds ratio, 0.96). In the MD group, 17 (60.7%) patients were vitamin D deficient, 6 (21.4%) insufficient, and only 5 (17.9%) sufficient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of this study show that serum vitamin D level in MD is significantly lower than that of the control group. However, the role of vitamin D supplementation in the management of MD needs further study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence:<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01945998211000395","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T03:42:44Z","timestamp":1616557364000},"page":"146-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association Between Serum Vitamin D Level and M\u00e9ni\u00e8re\u2019s Disease"],"prefix":"10.1002","volume":"166","author":[{"given":"Mehdi","family":"Bakhshaee","sequence":"first","affiliation":[{"name":"Sinus and Surgical Endoscopic Research Center Department of Otorhinolaryngology School of Medicine Mashhad University of Medical Sciences Mashhad 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