{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:17:59Z","timestamp":1785428279316,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Milton J. Dance Endowment"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe laryngeal findings and voice quality in patients with suspected lung cancer, relative to voice quality and possible laryngeal pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with known or suspected lung cancer were approached before planned thoracic surgery, and they completed acoustic analysis, the Voice\u2010Related Quality of Life (V\u2010RQOL) questionnaire, and stroboscopy. The prevalence of dysphonia, V\u2010RQOL and Cepstral Spectral Index of Dysphonia (CSID) scores, and laryngeal findings were examined and compared between patients ultimately found to have lung cancer and those without cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients (45 cancer, 16\u00a0noncancer) were analyzed. Patients with cancer were older than those without (mean \u00b1 SD, 72.3 \u00b1 9.94 vs 62.6 \u00b1 9.30 years; <jats:italic>P<\/jats:italic> =. 001). Otherwise, the distribution of stroboscopy findings, acoustic measures, and self\u2010reported voice handicap were similar between the cancer and noncancer cohorts. Prior to surgery, no patients had vocal cord paralysis or obvious neoplasm, though 4 (6.56%) had leukoplakia and 28 (45.9%) had vocal fold movement asymmetry on stroboscopy. Overall, 21 patients (35.0%) had average CSID scores &gt;19, and 13 (21.7%) had CSID scores &gt;24; however, only 4 self\u2010described their voice as not working as it should, and only 2 had a V\u2010RQOL score &lt;85.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with suspected lung cancer have moderate dysphonia on acoustic measures, though self\u2010reported impact on quality of life is low. While leukoplakia was seen in 4 patients, obvious neoplasm and occult paralysis were not seen in this cohort. Together, these findings suggest that patients with suspected lung cancer should be assessed for subjective voice dysfunction, but routine laryngeal screening may otherwise be unnecessary.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998211008382","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T04:32:53Z","timestamp":1618893173000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Voice Quality and Laryngeal Findings in Patients With Suspected Lung Cancer"],"prefix":"10.1002","volume":"166","author":[{"given":"Ruth J.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery School of Medicine Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Messing","sequence":"additional","affiliation":[{"name":"The Milton J. Dance Jr Head and Neck Center Johns Hopkins Voice Center at GBMC Healthcare Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neri M.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Department of Surgery GBMC Healthcare Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee M.","family":"Akst","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery School of Medicine Johns Hopkins University Baltimore Maryland USA"},{"name":"The Milton J. Dance Jr Head and Neck Center Johns Hopkins Voice Center at GBMC Healthcare Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Key statistics for lung cancer","author":"American Cancer Society","year":"2020","journal-title":"Published"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23798"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.102"},{"key":"e_1_2_9_5_1","unstructured":"HumphreyL DeffebachM PappasM et al.Screening for lung cancer: systematic review to update the US Preventive Services Task Force Recommendation. Published2013. 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