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This study utilized the National Library of Medicine\u2019s PubMed\/MEDLINE database to query for articles describing major outcomes in patients with COVID\u201019 with or without OD. Of the 1284 examined studies, 26 were included for a total of 11,408 patients (35.9% with OD). When compared with patients with OD, patients without OD were 5.3 times more likely to experience hospitalization (odds ratio, 5.28 [95% CI, 4.64\u20106.01]; <jats:italic>P<\/jats:italic> &lt;. 001), 7.0 times more likely to undergo intubation or ventilation (7.01 [5.52\u20108.90], <jats:italic>P<\/jats:italic> &lt;. 001), and 7.0 times more likely to die (6.97 [3.54\u201013.74], <jats:italic>P<\/jats:italic> &lt;. 001). This association between OD and COVID\u201019 outcomes may play an important role in patient risk stratification and counseling and early identification of potentially severe cases, and it may encourage future investigations regarding the infectivity and immune response to SARS\u2010CoV\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998211017442","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T04:02:50Z","timestamp":1621915370000},"page":"388-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association Between Olfactory Dysfunction and Critical Illness and Mortality in COVID\u201019: A Meta\u2010analysis"],"prefix":"10.1002","volume":"166","author":[{"given":"Khodayar","family":"Goshtasbi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck 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