{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:49:23Z","timestamp":1777330163658,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Electronic cigarettes (E\u2010cigs) are nicotine delivery systems with increasing popularity. The US Food and Drug Administration defines side effects as unwanted or unexpected events or reactions. Our objective was to examine the unintended otolaryngology\u2010related side effects associated with E\u2010cigs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Medline, EMBASE, CINAHL, Web of Science, and CENTRAL databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Study selection was independently performed by 2 authors in accordance with the PRISMA\u2010ScR statement (Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses Extension for Scoping Reviews); discrepancies were resolved by the senior author. English studies from database inception to May 1, 2020, with a sample size &gt;5 were included. In vitro, animal, and lower respiratory tract studies were excluded. The main outcome was defined as otolaryngology\u2010related side effects following E\u2010cig use. Levels of evidence per the Oxford Centre for Evidence\u2010Based Medicine were used to determine study quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1788 articles, 32 studies were included. The most common unintended side effects were throat irritation (n = 16), cough (n = 16), mouth irritation (n = 11), and oral mucosal lesions (n = 8). A large proportion of participants also reported conventional tobacco use in addition to E\u2010cigs. Eight studies investigated the effectiveness of vaping on smoking cessation. The quality of the literature was level 2 to 4. Given the significant heterogeneity in the studies, meta\u2010analysis was not performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The most reported side effects were throat and mouth irritation, followed by cough. The long\u2010term impact of E\u2010cigs is not known given the recent emergence of this technology. Future studies are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998211069502","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T12:00:41Z","timestamp":1641297641000},"page":"7-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Unintended Side Effects of Electronic Cigarettes in Otolaryngology: A Scoping Review"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4418-8215","authenticated-orcid":false,"given":"Ameen","family":"Amanian","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jobanjit","family":"Phulka","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda C.","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"US Food and Drug Administration.Vaporizers e-cigarettes and other electronic nicotine delivery systems (ENDS). 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